Parathyroid hormone (1-34) (rat) acetate

Parathyroid hormone (1-34) (rat) acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Parathyroid hormone (PTH) (1-34) is a synthetic N-terminal fragment of PTH that corresponds to amino acids 1-34 of mature PTH and a PTH receptor agonist.1,2 It induces β-arrestin recruitment in HEK293H cells expressing human PTH receptor type 1 (PTH1R; EC50 = 7.7 nM) and adenylyl cyclase activation in COS-7 cells expressing rat PTH2R (EC50 = 0.41 nM). PTH (1-34) (100 nM) induces hypertrophy of primary rat ventricular cardiomyocytes.3 It increases tibial bone mineral density in ovariectomized rats when administered at a dose of 5 µg/kg.4WARNING This product is not for human or veterinary use.

• Einzelnachweise

  [1] BRANDON H. KIM . Extracellular nucleotides enhance agonist potency at the parathyroid hormone 1 receptor[J]. Cellular signalling, 2018, 46: Pages 103-112. DOI: 10.1016/j.cellsig.2018.02.015
  [2] S R HOARE  T B U  T I Bonner. Comparison of rat and human parathyroid hormone 2 (PTH2) receptor activation: PTH is a low potency partial agonist at the rat PTH2 receptor.[J]. Endocrinology, 1999, 140 10: 4419-4425. DOI: 10.1210/endo.140.10.7040
  [3] X LIU  S L  R Xie. Rat parathyroid hormone 1-34 signals through the MEK/ERK pathway to induce cardiac hypertrophy.[J]. Journal of International Medical Research, 2008, 36 5: 942-950. DOI: 10.1177/147323000803600510
  [4] M GOWEN. Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.[J]. Journal of Clinical Investigation, 2000, 105 11: 1595-1604. DOI: 10.1172/jci9038

Parathyroid hormone (1-34) (rat) acetate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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