SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE

Bezeichnung:SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE

CAS-Nr127062-22-0

Englisch Name:SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE

CBNumberCB4141268

SummenformelC20H31N4NaO9S2

Molgewicht558.6

MOL-Datei127062-22-0.mol

SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	H2O: soluble10mg/mL
Aggregatzustand	powder
Farbe	White to off-white

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	61
S-Sätze:	53-45
WGK Germany	3
HS Code	29349990

Gefahreninformationscode (GHS)

SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
powder
Verwenden
Water soluble biotinylation reagent incorporating an aminocaproyl spacer. This can reduce the steric hindrance in binding avidin to some biotinylated compounds. Has also been used as a cell surface labeling reagent. Typically coupled to primary amine in the pH range 6.5-8.5. May be used for the biotinylation of cell surface proteins.
Allgemeine Beschreibung
Biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt is a water soluble biotinylation reagent. It can be used in immunoprecipitation of signaling proteins. It can also be used in analysis of hyaluronan synthesis. Further, the product can also be used in ELISA. This biotinylation reagent has shown specificity for human dermal fibroblasts.
Biologische Aktivität
sulfo-nhs-lc-biotin (sulfosuccinimidyl 6-(biotinamido) hexanoate) is an amine-reactive biotinylation agent. as a water-soluble analog of nhs-lc-biotin, sulfo-nhs-lc-biotin contains a negatively charged sulfonate group on the nhs ring structure, which creates sufficient polarity within the molecule and allows it to be directly added into aqueous reactions without prior dissolution of organic solvents. sulfo-nhs-lc-biotin covalently binds to amine groups in proteins and other molecules through its nhs ester forming an amide linkage and releasing n-hydroxysuccinimide. sulfo-nhs-lc-biotin has a greater length (22.4 a) between a covalently modified molecule and the bicyclic biotin rings than nhs-biotin (13.5 a), which provides the probes a greater opportunity to reach the binding sites deeply buried inside the surface plane of proteins.bioconjugate techniques , 2nd ed. by greg t.hermanson (pierce biotechnology, thermo fisher scientific, rockford, il). academic press (an imprint of elsevier): london, amsterdam, burlington, san diego . 2008. isbn 978-0-12-370501-3.

SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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