LG 83-6-05

LG 83-6-05 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  LG 83-6-05 is a novel sodium channel blocking agent.

• in vivo

  In enzymatically-dispersed single ventricular cardiomyocytes of adult rats and guinea pigs the inhibition of the cardiac sodium current by a novel sodium channel blocking agent (LG 83-6-05, 1-[3-(2-Hydroxy-3-(2-methylpropylamino)-propoxy)-4-methyl-2- thienyl++ ]-3-phenyl-1-propanon hydrochloride) was studied. A single-electrode voltage-clamp system (switch clamping, patch electrodes) was used to measure action potentials as well as ionic currents during voltage-clamp experiments. In addition single channel measurements were performed using the patch-clamp technique. The single cell system enabled this study to demonstrate that LG 83-6-05 is an inhibitor of the cardiac sodium current._x000D_ _x000D_ Reference: Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. https://pubmed.ncbi.nlm.nih.gov/1965329/

• target

  LG 83-6-05 is a novel sodium channel blocking agent.

LG 83-6-05 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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