2-Iodophenylacetic acid

Bezeichnung:2-Iodophenylacetic acid

CAS-Nr18698-96-9

Englisch Name:2-Iodophenylacetic acid

CBNumberCB4131159

SummenformelC8H7IO2

Molgewicht262.04

MOL-Datei18698-96-9.mol

2-Iodophenylacetic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	116-119 °C (lit.)
Siedepunkt	344.5±17.0 °C(Predicted)
Dichte	1.885±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Powder
pka	pK1:4.038 (25°C)
Farbe	Cream
Sensitive	Light Sensitive
BRN	2086800
CAS Datenbank	18698-96-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37
WGK Germany	3
Hazard Note	Irritant/Light Sensitive
HazardClass	IRRITANT, LIGHT SENSITIVE
HS Code	29163990

Gefahreninformationscode (GHS)

2-Iodophenylacetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Cream powder
Application
2-Iodophenylacetic acid may be used in the preparation of:
2-iodophenylacetyl chloride
3,4-dimethoxyphenyl 2-iodophenylacetate
N-{2-[2-(2-iodophenyl)-acetylamino]-ethyl}-2-(3,4- dichlorophenyl)-acetamide
Verwenden
2-Iodophenylacetic acid is a synthetic intermediate that is widely used in the chemical, pharmaceutical and cosmetic industries. 2-Iodophenylacetic acid is also used as a reagent to synthesize Cepharanone B, a natural and potentially antineoplastic aristolactam that is found in Piper longum (a medicinal plant native to India).
synthetische
synthesis of 2-Iodophenylacetic acid: The anthranilic acid solution was acidified with sulfuric acid to pH = 1 followed by a diazotization reaction. The diazonium was added dropwise to the potassium iodide-sulfuric acid solution (3.5 g KI, 1.0 mL concentrated H2SO4, 5 mL water) preheated to 60-70 °C, stirred for 30 min, placed overnight, and filtered to obtain the product. Recrystallization with 50% ethanol aqueous solution gave 3.83 g of 2-iodophenylacetic acid, the yield was 73% (calculated as o-nitrophenylacetic acid), and the melting point was 113-115 °C (117 °C reported in the literature).
Allgemeine Beschreibung
2-Iodophenylacetic acid is a substituted acetic acid that can be prepared from 2-iodobenzyl cyanide. It undergoes palladium-catalyzed reaction with allenes to form 1,3-butadienes. 2-Iodophenylacetic acid also undergoes photolysis in carbon tetrachloride to form the corresponding chloro compound.

2-Iodophenylacetic acid Upstream-Materialien And Downstream Produkte

2-Iodophenylacetic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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