NSC403140 Struktur

NSC403140

Bezeichnung:NSC403140

CAS-Nr466-75-1

Englisch Name:NSC403140

CBNumberCB41250334

SummenformelC17H19NO4

Molgewicht301.33706

MOL-Datei466-75-1.mol

NSC403140 physikalisch-chemischer Eigenschaften

storage temp.	Store at -20°C
Löslichkeit	DMSO : 100 mg/mL (331.85 mM; Need ultrasonic)
Aggregatzustand	Solid
Farbe	White to off-white

NSC403140 Chemische Eigenschaften,Einsatz,Produktion Methoden

Definition
ChEBI: Haemanthamine is an alkaloid.
Biologische Aktivität
Haemanthamine is a rhodophylline-like alkaloid isolated from the Amaryllidaceae plant with potent anticancer activity. It targets the ribosome to inhibit protein biosynthesis during the elongation phase of translation, and has proapoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities.

in vitro

Haemanthamine (1-100 μM; 24-48 hours; A2780 cells) treatment shows a time- and dose-dependent decrease in cell viability.
Haemanthamine (10 μM; 24-72 hours; A2780 cells) treatment leads to a significant inhibition of A2780 cell proliferation.
Haemanthamine binds at the A-site cleft of the peptidyl transferase center on the large ribosomal subunit, creating unique molecular interactions with the 25S rRNA. Haemanthamine has a highly specific inhibitory effect on pre-rRNA processing, leading to the activation of a p53-dependent antitumoral surveillance pathway known as nucleolar stress.

Cell Viability Assay

< td class="col1"> Cell Line:

A2780 ovarian cancer cells
Concentration:	1 μM, 10 μM, 50 μM, 100 μM
Incubation Time:	24 hours, 48 hours
Result:	Showed a time- and dose-dependent decrease in cell viability.

Cell Proliferation Assay

Cell Line:	A2780 ovarian cancer cells
Concentration:	10 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Led to a significant inhibition of A2780 cell proliferation.

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in vivo

A pharmacokinetic study of Haemanthamine in rats shows a rapid distribution phase of 30 min, a half-life of 70.4 min, and a major clearance through renal elimination. The high distribution volume of 13.7 L/kg suggests a high intracellular penetration, and its plasmatic concentration remains higher than 1 μM for at least 1 hr after a single 10-mg/kg administration.

NSC403140 Upstream-Materialien And Downstream Produkte

NSC403140 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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