Fludiazepam

Bezeichnung:Fludiazepam

CAS-Nr3900-31-0

Englisch Name:Fludiazepam

CBNumberCB4115212

SummenformelC16H12ClFN2O

Molgewicht302.73

MOL-Datei3900-31-0.mol

Fludiazepam physikalisch-chemischer Eigenschaften

Schmelzpunkt	88-92°; mp 69-72° (Sternbach)
Siedepunkt	498.1±45.0 °C(Predicted)
Dichte	1.3159 (estimate)
Löslichkeit	DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
Aggregatzustand	A crystalline solid
pka	pKa 2.29±0.009(H2O) (Uncertain)
NIST chemische Informationen	Fludiazepam(3900-31-0)

Sicherheit

Toxizität

LD50 in mice (mg/kg): 910 orally; 360 i.p.; 1150 s.c. (Asami)

Fludiazepam Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fludiazepam (Item No. 22424) is an analytical reference standard categorized as a benzodiazepine. Fludiazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Originator
Erispan,Sumitomo,Japan,1981
Verwenden
Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Definition
ChEBI: Fludiazepam is a 1,4-benzodiazepinone, an organochlorine compound and an organofluorine compound. It has a role as an anxiolytic drug. It is functionally related to a monofluorobenzene and a diazepam.
Manufacturing Process
A solution of 60 g of chromic anhydride in 40ml of water was added dropwise to a suspension of 60 g of 2-aminomethyl-1-methyl-5-chloro-3-(ofluorophenyl)- indole hydrochloride in 600 ml of acetic acid. The mixture was stirred at room temperature overnight. To the reaction mixture was added 1.1 liters of ether and 1 liter of water and then 800 ml of 28% ammonium hydroxide, in small portions. The ethereal layer separated, washed with water, dried, and concentrated under reduced pressure. The residue (51.8 g) was dissolved in 100 ml of ethanol, and 100 ml of 20% ethanolic hydrogen chloride was added to the solution and the mixture was cooled. The precipitate was collected by filtration to yield 46.5 g of 1-methyl-7-chloro-5- (o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one hydrochloride, melting point 218°C (decomposed). Recrystallization from ethanol raised the melting point to 218.5°C to 219°C (decomposed).
Therapeutic Function
Anxiolytic

Fludiazepam Upstream-Materialien And Downstream Produkte

3900-31-0, Fludiazepam Verwandte Suche:

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