Polyoxyethylene stearate

Bezeichnung:Polyoxyethylene stearate

CAS-Nr9004-99-3

Englisch Name:Polyoxyethylene stearate

CBNumberCB4111623

Summenformel(C2H4O)nC18H36O2

Molgewicht622.91

MOL-Datei9004-99-3.mol

Polyoxyethylene stearate physikalisch-chemischer Eigenschaften

Schmelzpunkt	47 °C
Flammpunkt	39 °C
storage temp.	2-8°C
Wasserlöslichkeit	Soluble in water
Löslichkeit	Chloroform (Slighty), Methanol (Slightly)
Aggregatzustand	powder to lump
Farbe	White to Almost white
Geruch (Odor)	at 100.00?%. mild fatty
hydrophiles-lipophiles Gleichgewicht (HLB)	18.8
LogP	7.629 (est)
EPA chemische Informationen	Polyethylene glycol monostearate (9004-99-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	1
RTECS-Nr.	MD0907300
HS Code	3907200000
Giftige Stoffe Daten	9004-99-3(Hazardous Substances Data)
Toxizität	LD50 oral in rabbit: > 12mL/kg

Gefahreninformationscode (GHS)

Polyoxyethylene stearate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Waxy, light-tan solid; nearly odorless. Congealing range 39–45C. Soluble in water, alcohol, ether, and acetone; insoluble in mineral and vegetable oils.
Verwenden
Pegosperse(R) 1500 MS is a mixture of polyethylene glycol esters. It is compatible with lipophilic compounds due to a higher free fatty acid content. Suggested applications: cosmetic formulations, lubricants.
Pegosperse(R) 1750 MS is a high molecular weight, high HLB surface active agent suggested for use in cosmetic formulations (emulsifier, viscosity modifier) and lubricants (emulsifier).
Pegosperse(R) 400 MS is a multifunctional surface active agent suggested for use in cosmetic formulations, household products, lubricants, textile chemicals, polishes and paper.
PEG-5 stearate, an emulsifier, is listed as particularly applicable for hand and body lotions and creams.
Verwenden
Polyoxyethylene stearate is an emulsifier and antifoaming agent used in processed foods, fruit jellies, and sauces.
Definition
Polyoxyethylene stearate is a mixture of the monoand diesters of stearic acid and mixed polyoxyethylene diols having an average polymer length of 7.5 oxyethylene units.
Trademarks
Myrj 53 (ICI Americas).
Allgemeine Beschreibung
Polyoxyethylene (40) stearate is a neutral surfactant.
Sicherheitsprofil
Very slightly toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also other polyethylene glycol monostearate entries and POLYETHYLENE GLYCOL.
in vitro
Polyoxyethylene stearate has been recommended as an additive to the radiolabelled 7H12 Middlebrook TB media and, as such, has been shown to enhance the growth of mycobacteria in the radiometric BACTEC rapid culture system. Polyoxyethylene (50) stearate produces the greatest enhancement in growth and reduction in the time taken to detect growth for M. tuberculosis and polyoxyethylene (30) stearate and polyoxyethylene (JL) stearate for species of mycobacteria other than M. tuberculosis. Polyoxyethylene stearate inhibits P-gp mediated efflux in a concentration-dependent manner mainly by modulating substrate-stimulated P-gp ATPase activity. Polyoxyethylene 40 stearate reduces vinblastine sulfate efllux. The cytotoxicity of vinblastine to K562/ADR cells is significantly enhanced when cotreated with 100 or 150 μg/mL polyoxyethylene 40 stearate.
in vivo
Polyoxyethylene stearate is potentially useful as a pharmaceutical ingredient to improve the oral bioavailability of coadministered P-gp substrates and substrates for certain CYP isoforms. The average tumour volume and weight are significantly less in the polyoxyethylene 40 stearate+vinblastine groups. The inhibition rate for tumor growth is increased from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group).

Polyoxyethylene stearate Upstream-Materialien And Downstream Produkte

Polyoxyethylene stearate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

9004-99-3, Polyoxyethylene stearate Verwandte Suche:

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