NEUROPEPTIDE S (HUMAN)

NEUROPEPTIDE S (HUMAN) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.

• in vitro

  Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC ₅₀ of 6.7 ± 2.4 nM, the binding of [ ^{125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K _d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ 125I I] Y10-NPS, [ 125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC ₅₀ = 0.42 ± 0.12 nM).}

• in vivo

  Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .

  Animal Model:	Male C57Bl/6 mice
  Dosage:	0.1 nM, 1 nM
  Administration:	Intracerebroventricular (icv) injection
  Result:	Increased locomotor activity and promoted wakefulness.

• target

  EC50: 9.4 nM (neuropeptide S receptor)

NEUROPEPTIDE S (HUMAN) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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