10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Pacatal,Warner Lambert,US,1957

• Manufacturing Process

  A 500 cc flask equipped with a mechanical stirrer, reflux condenser and a soda-lime tube was filled with 230 cc of absolute xylene, 27.5 g of 1-methyl3-bromomethylpiperidine, 53.3 g of phenothiazine and 14.2 g of finely powdered sodium amide, and the solution was heated under reflux for 6 hours. After cooling water was added and the batch was extracted with ether. As the hydrochloric acid salt of the obtained phenothiazine derivative is difficultly soluble in water, the further processing was carried out by way of the acetate. The etheric solution was extracted several times in a separating funnel with dilute acetic acid. The combined aqueous extracts were basified, extracted with ether, dried with potassium carbonate and, after removal of the ether, distilled in vacuo.
  Yield = 64%; boiling point 230°C to 235°C at 4 mm; melting point of hydrochloride is 180°C to 181°C.

• Therapeutic Function

  Tranquilizer

10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Upstream-Materialien And Downstream Produkte

10-((1-Methyl-3-piperidinyl)-methyl)-10H-phenothiazin-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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