Eletriptan hydrobromide

Bezeichnung:Eletriptan hydrobromide

CAS-Nr177834-92-3

Englisch Name:Eletriptan hydrobromide

CBNumberCB3854925

SummenformelC22H27BrN2O2S

Molgewicht463.43

MOL-Datei177834-92-3.mol

Eletriptan hydrobromide physikalisch-chemischer Eigenschaften

Schmelzpunkt	169-171?C
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO: >10mg/mL
Aggregatzustand	powder
Farbe	off-white to light tan
InChIKey	PWVXXGRKLHYWKM-IBGZPJMESA-N

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	26
WGK Germany	3
HS Code	29339900

Gefahreninformationscode (GHS)

Eletriptan hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Eletriptan hydrobromide is Tan Solid
Originator
Relpax,Pfizer
Verwenden
Relpax is a second generation triptan drug used in the treatment of migraine headaches.
Verwenden
antibiotic
Verwenden
Eletriptan hydrobromide is a second generation triptan drug used in the treatment of migraine headaches.
Definition
ChEBI: Eletriptan hydrobromide is a hydrobromide. It has a role as a serotonergic agonist, a vasoconstrictor agent and a non-steroidal anti-inflammatory drug. It contains an eletriptan(1+).
Manufacturing Process
A mixture of the appropriate phenyl vinyl sulfone, tri-o-tolylphosphine, palladium (II) acetate, triethlamine and (R)-5-bromo-3-(Nmethylpyrrolidinylmethyl)-1H-indole in anhydrous acetonitrle was heated at reflux under nitrogen. The resultant reaction mixture was evaporated under reduced pressure, and the residue was column chromatographed using silica gel and elution with methylene chloride/absolute ethanol/ammonia to afford the (R )-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)- 1H-indole.
A solution of (R)-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2- ylmethyl)-1H-indole and 10% Pd/C in ethanolic hydrogen chloride (prepared from absolute ethanol and acetyl chloride and N,N-dimethylformamide was shaken under a hydrogen atmosphere at room temperature). The resultant reaction mixture was filtered through diatomaceous earth (Celite trademark), washed with absolute ethanol, and the combined filtrates were evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic phase was separated, washed with water, brine, dried(Na2SO4), and evaporated under reduced pressure to afford a oil product. Column chromatography of this product using silica gel and elution with methylene chloride/absolute ethanol/ammonia afforded the appropriate (R)-5- (2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole.
The salt eletriptan hydrobromide may be produced by reaction of the (R)-5- (2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole with hydrobromic acid.
Trademarks
Relpax (Pfizer).
Therapeutic Function
Serotonin agonist
Biologische Aktivität
Orally active, selective 5-HT 1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo . Displays antimigraine activity.
Lager
room temperature (desiccate)

Eletriptan hydrobromide Upstream-Materialien And Downstream Produkte

Eletriptan hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

177834-92-3, Eletriptan hydrobromide Verwandte Suche:

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