11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

Bezeichnung:11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

CAS-Nr111974-74-4

Englisch Name:11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

CBNumberCB3854879

SummenformelC17H18ClN3S

Molgewicht331.86

MOL-Datei111974-74-4.mol

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	180-184°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Soluble in DMSO, Methanol, Distilled Water
Aggregatzustand	solid
Farbe	Off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
InChI	InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey	MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES	C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS Datenbank	111974-74-4(CAS DataBase Reference)

Sicherheit

HS Code

2934990002

Gefahreninformationscode (GHS)

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemische Eigenschaften
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
Verwenden
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
Verwenden
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
Einzelnachweise
1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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