Piperidin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H302：Gesundheitsschädlich bei Verschlucken.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Piperidine Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.

• CHEMISCHE GEFAHREN

  Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Stickstoffoxiden. Mittelstarke Base. Reagiert sehr heftig mit Oxidationsmitteln. Reagiert sehr heftig mit Dicyanofurazan, N-Nitrosoacetanilid und 1-Perchlorylpiperidin unter Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Inhalation des Dampfes in hoher Konzentration kann zu Lungenödem führen (s.Anm.). Die Auswirkungen treten u.U. verzögert ein. ärztliche Beobachtung notwendig.

• LECKAGE

  Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R61:Kann das Kind im Mutterleib schädigen.
  R10:Entzündlich.
  R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.
  R34:Verursacht Verätzungen.
  R23/24:Giftig beim Einatmen und bei Berührung mit der Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

• Aussehen Eigenschaften

  C5H11N; (Hexahydropyridin; Pentamethylenimin). Farblose, nach Ammoniak riechende Flüssigkeit.

• Gefahren für Mensch und Umwelt

  Piperidin zersetzt sich schlagartig oberhalb 110鳦. Mit starken Oxidationsmitteln kann es zu explosionsartigen Reaktionen kommen. Die Dämpfe sind viel schwerer als Luft und bilden mit Luft explosionsfähige Gemische.
  Verursacht starke Reizungen nach Augen- und Hautkontakt. Inhalation führt zu Schleimhautreizungen, Husten und Atemnot. Nach Verschlucken kommt es zu Übelkeit und Erbrechen, Schleimhautirritationen im Mund, Rachen, Speiseröhre und Magen-Darmtrakt. Nach Resorption kommt es zu Speichelfluß, Atemnot, Muskelbeschwerden und Blutdruckanstieg. Nach Aufnahme größerer Mengen an den Beinen beginnende allmählich aufsteigende Lähmung bis zur Atemlähmung bei vollem Bewu&szzlig;tsein.
  Wassergefährdender Stoff (WGK 2).

• Schutzmaßnahmen und Verhaltensregeln

  Alle Arbeiten im Abzug durchführen.
  Latex-Schutzhandschuhe nur als kurzfristiger Spritzschutz.

• Verhalten im Gefahrfall

  Mit flüssigkeitsbindendem Material (z.B. Rench Rapid, Chemizorb) aufnehmen und der Entsorgung zuführen. Mit Wasser nachreinigen.
  Wasser, Kohlendioxid, Pulver, Schaum.

• Erste Hilfe

  Nach Hautkontakt: Mit reichlich Wasser und Seife abwaschen.
  Nach Augenkontakt: Bei geöffnetem Lidspalt mind. 10 Min. mit Wasser spülen. Augenarzt konsultieren.
  Nach Einatmen: Für viel Frischluft sorgen. Bei Atemstillstand Atemspende oder Gerätebeatmung.
  Nach Verschlucken: Erbrechen auslösen. Sofort Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
  Laxans: Natriumsulfat (1Eßl. auf 1/4 l Wasser).
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll entsorgen.

• Chemische Eigenschaften

  Clear or slightly yellow liquid

• Chemische Eigenschaften

  Piperidine has a heavy, sweet, floral, animal odor and a burning peppery taste.

• Chemische Eigenschaften

  Piperidine is a strong base (pK_b = 2.88) that reacts vigorously with oxidizing materials, is easily ignited, and forms explosive vapor concentrations at room temperature. When heated to decomposition it gives off toxic fumes of NO_x (Sax 1984). It behaves like an aliphatic secondary amine and can form complexes with salts of heavy metals (HSDB 1988).

• Chemische Eigenschaften

  Piperidine is a clear, colorless liquid. Pepper, ammonia or amine odor.

• Occurrence

  Piperidine occurs at low levels in a variety of food products (Neurath et al 1977), including baked ham (0.2 p.p.m.), milk (0.11 p.p.m.) coffee (1 p.p.m. dry) (Singer and Lijinsky 1976) and canned fish (Tanikawa and Motohiro 1960). It is also found in black pepper (Windholz 1983), hemp (Obata and Ishikawa 1960), hemlock (Cromwell 1956) and tobacco (Furia and Bellanca 1975). Piperidine is a natural constituent of skin (Sax and Lewis 1987), human urine (Von Euler 1944), brain (Honegger and Honegger 1960) and cerebrospinal fluid (Perry et al 1964). Humans excrete about 3-20 mg/d in the urine (Reinhardt and Britelli 1981).

• Verwenden

  It is used in organic synthesis, especially inthe preparation of many crystalline derivativesof aromatic nitro compounds.

• Verwenden

  Fits Applied Biosystems 431 and 433A peptide synthesizers.

• Verwenden

  Piperidine is an organic heterocyclic amine widely used as building block and reagent in the synthesis of organic compounds including pharmaceuticals.

• Application

  The secondary amine piperidine is highly reactive and is therefore frequently employed as an intermediate for pharmaceuticals and for plant protection agents. It is also used as a vulcanization accelerator in rubber manufacture and as an oil or fuel additive. Piperidine and, in many cases, piperidine acetate are useful catalysts for condensation reactions, e.g., the Knoevenagel reaction, aldol condensation, and the condensation of a nitroparaffin with an aldehyde. However, for the last of these reactions, diethylamine is the preferred catalyst. The use of piperidine is particularly advisable where the reactants or products are unstable in the presence of stronger bases.
  

• synthetische

  Usually prepared by electrolytic reduction of pyridine.

• Definition

  piperidine: A saturated heterocycliccompound having a nitrogen atom ina six-membered ring, C₅H₁₁N; r.d.0.86; m.p. –7°C; b.p. 106°C. The structureis present in many alkaloids

• Vorbereitung Methode

  Piperidine is usually prepared by the electrolytic reduction of pyridine. It may also be obtained by heating piperidine with alcoholic KOH or by the cyclization of 1,5-diaminopentane hydrochloride (Windholz 1983). U.S. production in 1983 was approximately 606,000 pounds (HSDB 1988). Commercial piperidine is supplied in two grades, 95 and 98 percent pure (Sax and Lewis 1987).

• Definition

  ChEBI: An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine.

• Trademarks

  Cypentil (Abbott).

• Aroma threshold values

  Detection: 65.8 to 70.6 ppm

• Allgemeine Beschreibung

  A clear colorless liquid with a pepper-like odor. Less dense than water, but miscible in water. Will float on water. Flash point 37°F. Melting point -15.8°F (-9°C). Boiling point 222.8°F (106°C). May severely irritate skin and eyes. May be toxic by ingestion and inhalation. Vapors heavier than air. Used to make rubber and as a solvent.

• Air & Water Reaktionen

  Highly flammable. Miscible in water.

• Reaktivität anzeigen

  1-Oxa-4-azacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

• Health Hazard

  Piperidine is a highly toxic compound. Theacute oral toxicity is high in many species oftest animals. The oral LD50 values in miceand rabbits are 30 and 145 mg/kg, respectively(NIOSH 1986). The liquid is moderatelytoxic by skin absorption. Inhalationtoxicity in experimental animals was low,however. A 4-hour exposure to 4000 ppmwas lethal to rats. Piperidine is corrosive toskin. Contact with eyes can produce severeirritation.

• Health Hazard

  An irritation threshold of 26 p.p.m. has been reported from studies on human volunteers (Bazarova and Migukina 1975). Levels of 2 to 5 p.p.m. in air have been recorded during the transfer of piperidine from drums in a semi-closed system. At this level, the vapors were intolerable but no irritation was observed (ANON 1982). In an accidental case of skin exposure, third-degree burns developed after only 3 min of skin contact (Linch 1965). Piperidine has a pronounced emetic effect in humans. When administered to schizophrenic patients at doses of 1 to 6 g/d, it was shown to cause nausea and a subjective sense of well being (Giacobini 1976; Tasher et al 1960). The primary, but low-level, means of human exposure, however, is from the natural piperidine content of foods (HSDB 1988).

• Health Hazard

  Strong local irritant and may cause permanent injury after short exposure to small amounts. Ingestion may involve both irreversible and reversible changes. 30 to 60 mg/kg may cause symptoms in humans.

• Brandgefahr

  1-Oxa-4-azacyclohexane evolves explosive concentrations of vapor at normal room temperatures. When heated to decomposition, 1-Oxa-4-azacyclohexane emits highly toxic fumes of nitrogen oxides. Dangerous, when exposed to heat, flame, or oxidizers. Avoid 1-Perchloryl1-Oxa-4-azacyclohexane and oxidizing materials. 1-Oxa-4-azacyclohexane is a reactive compound and forms complexes with the salts of heavy metals. 1-Oxa-4-azacyclohexane evolves explosive concentrations of vapor at normal room temperatures. Keep away from igniting sources and heat.

• Flammability and Explosibility

  Highly flammable

• Industrielle Verwendung

  Piperidine is used as a solvent, a curing agent for rubber and epoxy resins, a catalyst in silicone esters, an intermediate in organic synthesis and as a complexing agent (HSDB 1988; Reinhardt and Britelli 1981). It is a trace constituent in oils and fuels (Sax and Lewis 1987). It is used in the manufacture of local anesthetics, analgesics and other pharmaceuticals, and also for wetting agents and germicides (Gehring 1983). It is also used as a flavor additive in soups, meats, condiments, baked goods, candy and non-alcoholic beverages at 0.05-5.0 p.p.m. (Furia and Bellanca 1975).

• Sicherheitsprofil

  Poison by ingestion, skin contact, and intraperitoneal routes. Moderately toxic by subcutaneous route. Mildly toxic by inhalation. An experimental teratogen. Experimental reproductive effects by inhalation. A skin irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Can react vigorously with oxidzing materials. To fight fire, use alcohol foam, CO2, dry chemical. Explodes on contact with 1- perchloryl-piperidme, dqanofurazan, N- nitrosoacetadde. When heated to decomposition it emits highly toxic fumes of NOx. Used in agriculture and pharmaceuticals, and as an intermediate for rubber accelerators. Used in production of drugs of abuse.

• mögliche Exposition

  Piperidine is used in agriculture and pharmaceuticals; intermediate for rubber accelerators; as a solvent; as a curing agent for rubber and epoxy resins; catalyst for condensation reactions; as an ingredient in oils and fuels; complexing agent; manufacture of local anesthetics; in analgesics; pharmaceuticals, wetting agents; and germicides; synthetic flavoring. Not registered as a pesticide in the Unied States.

• Carcinogenicity

  No tumors were produced in rats given piperidine (0.09%) in drinking water for 1 year. Mice receiving 19 doses of 50 mg/kg by intraperitoneal injection within 61 weeks followed by an 18-week observation period showed no increase in cancer incidences (251). Piperidine and sodium nitrite given together also failed to produce tumors. The failure of this treatment was surprising because nitrosopiperidine induced a high incidence of lung and esophageal tumors. The authors suggest that the relative strong basicity of piperidine reduced the rate of reaction with nitrite to such an extent that an ineffective amount of nitrosopiperidine was formed. In mice that had cholesterol pellets containing piperidine implanted in their bladders and were given sodium nitrite in their drinking water, an increase in bladder cancers was produced. Piperidine given as a series of 24 injections in groups of mice failed to produce lung tumors in the strain A mouse cancer screen. When piperidine and sodium nitrite were incubated in the isolated rat urinary bladder, nitrosopiperidine was detected in the bladder contents. No studies designed to evaluate the carcinogenic potential of piperidine alone following lifetime exposures have been reported.

• Stoffwechsel

  Piperidine is readily absorbed through the gastrointestinal tract, skin and lungs (HSDB 1988). In hens, 35 to 70% of an injected dose is rapidly excreted unchanged in the urine (Williams 1959; Sperber 1949). Rabbits also excrete piperidine unchanged (Hildebrandt 1900). When injected intraventricularly into rats, piperidine disappeared exponentially with a half-life of 20 min (Meek 1973). In a more recent study, Okano et al (1978) found that in rats most of an i.p. dose of [3H]-piperidine was excreted unchanged. Two major metabolites were identified as 3- and 4-hydroxypiperidine. Both compounds were also found in untreated animals and thus are probably metabolites of piperidine of exogenous or endogenous origin. These metabolites represent a detoxification mechanism, since they lack the potent pharmacological activities of the parent compound. Two unidentified metabolites were assumed to be conjugates. In a much earlier study, Novello et al (1926) claimed that piperidine was excreted as the ethereal sulfate. Metabolic studies of analgesics and anesthetics containing the piperidine ring have demonstrated the occurrence of N-hydroxylation, formation of a 6-oxo-derivative, and C-oxidative ring cleavage (Oelschlager and Al Shaik 1985). N-nitrosopiperidine has been synthesized from piperidine and sodium nitrite in the gastric contents,R.L. Reed isolated stomach and isolated small intestine of rats (Alam et al 1971; Epstein 1972).

• Versand/Shipping

  UN2401 Piperidine, Hazard Class: 8; Labels: 8-Corrosive material, 3-Flammable liquid.

• läuterung methode

  Dry piperidine with BaO, KOH, CaH2, or sodium, and fractionally distil (optionally from sodium, CaH2, or P2O5). Purify from pyridine by zone melting. [Beilstein 22 H 6, 22

• Inkompatibilitäten

  Piperidine is a highly flammable liquid. Vapor may form explosive mixture with air (at room temperature). A medium-strong base. Reacts violently with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Piperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Piperidine Upstream-Materialien And Downstream Produkte

110-89-4, Piperidine Verwandte Suche: