NOBILETIN

Bezeichnung:NOBILETIN

CAS-Nr478-01-3

Englisch Name:NOBILETIN

CBNumberCB3740677

SummenformelC21H22O8

Molgewicht402.39

MOL-Datei478-01-3.mol

NOBILETIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	136.0 to 140.0 °C
Siedepunkt	587.9±50.0 °C(Predicted)
Dichte	1.244±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Soluble in DMSO (up to 10 mg/ml)
Aggregatzustand	Solid
Farbe	White
BRN	360887
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	MRIAQLRQZPPODS-UHFFFAOYSA-N
CAS Datenbank	478-01-3(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	DJ3052200
HS Code	29329990

NOBILETIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Nobiletin (478-01-3) is a natural product isolated from citrus peels.? It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice?via?a?Clock?gene-dependent mechanism.1? Nobiletin directly bound to and activated RORα/γ.? Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
Chemische Eigenschaften
White powder
Verwenden
matrix metaloproteinase inhibitor; antineoplastic
Verwenden
Nobiletin is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. It is a potent antioxidant with good bioavailability. Nobiletin directly inhibits the ATP-binding cassette proteins P-glycoprotein and breast cancer resistance protein.
Definition
ChEBI: A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.
benefits
Nobiletin improved cognitive deficits and the pathological features of AD, such as Aβ pathology, hyperphosphorylation of tau, and oxidative stress, in animal models of AD. In addition, nobiletin improved motor and cognitive deficits in PD animal models. These observations suggest that nobiletin has the potential to become a novel drug for the treatment and prevention of neurodegenerative diseases such as AD and PD.
Einzelnachweise
1) He?et al.?(2016),?The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome; Cell Metabolism,?23?610 2) Mulvihill?et al.?(2011),?Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance; Diabetes?60?1446 3) Cui?et al.?(2010),?Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation; Biol. Pharm. Bull.,?33?1814 4) Nagase?et al.?(2005),?Mechanism of neurotrophic action of nobiletin in PC12D cells; Biochemistry?44?13683 5) Walle (2007),?Methoxylated flavones, a superior cancer chemopreventative flavonoid subclass?;?Semin. Cancer Biol.?17?354

NOBILETIN Upstream-Materialien And Downstream Produkte

NOBILETIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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