Sulindac Produkt Beschreibung

Sulindac Struktur
38194-50-2
  • CAS-Nr.38194-50-2
  • Bezeichnung:Sulindac
  • Englisch Name:Sulindac
  • Synonyma:Sulindac
    Sudac;Aclin;Saldac;MK-231;ReuMyl;AFLODAC;mobilin;Imbaral;SULINOL;clinoril
  • CBNumber:CB3740374
  • Summenformel:C20H17FO3S
  • Molgewicht:356.41
  • MOL-Datei:38194-50-2.mol
Sulindac physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :182-185°C
  • Dichte :1.2581 (estimate)
  • storage temp.  :Store at RT
  • Löslichkeit :Very slightly soluble in water, soluble in methylene chloride, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
  • Aggregatzustand :neat
  • pka :pKa (25°) 4.7
  • Wasserlöslichkeit :Soluble in water, methanol, ethanol.
  • maximale Wellenlänge (λmax) :327nm(0.05mol/L methanolic HCl)(lit.)
  • Merck  :14,8982
  • CAS Datenbank :38194-50-2(CAS DataBase Reference)
  • NIST chemische Informationen :Sulindac(38194-50-2)
Sicherheit
  • Kennzeichnung gefährlicher :Xn
  • R-Sätze: :22-63-42/43
  • S-Sätze: :-
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS-Nr. :NK8226000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29309090

Sulindac Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R63:Kann das Kind im Mutterleib möglicherweise schädigen.
    R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
  • Chemische Eigenschaften Yellow Crystalline Solid
  • Verwenden A non-steroidal anti-inflammatory agent. An anti-inflammatory
  • Verwenden Sulindac is a non-steroidal anti-inflammatory drug.
  • Definition ChEBI: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the ara position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
  • Indications Sulindac (Clinoril) is chemically related to indomethacin and is generally used for the same indications. It is a prodrug that is metabolized to an active sulfide metabolite and an inactive metabolite. The most frequently reported side effects are GI pain, nausea, diarrhea, and constipation. The incidence of these effects is lower than for indomethacin, presumably because sulindac is a prodrug and thus the active metabolite is not highly concentrated at the gastric mucosa. As with indomethacin, a rather high incidence of CNS side effects (dizziness, headache) also occurs.
  • Trademarks Clinoril (Merck).
  • Allgemeine Beschreibung Sulindac, (Z)-5-fluoro-2-methyl-1-([p-(methylsulfinyl)phenyl]methylene)-1H-indene-3-acetic acid (Clinoril), isan NSAID prodrug that contains a chiral sulfoxide moietybut is marketed as the racemate because it undergoes invivo reduction by the hepatic enzymes into its achiral, activemetabolite, methyl sulfide that exhibits potent andnonselective COX inhibition similar to indomethacin.
    The parent sulfoxide has a plasma half-life of 8 hours, andthe active methyl sulfide metabolite is 16.4 hours. The morepolar and inactive sulfoxide is virtually the only form excretedinto the renal tubules, thus sulindac is believed to haveminimal nephrotoxicity associated with indomethacin. Thelong half-life of sulindac is caused by the extensive enterohepaticcirculation and reactivation of the inactive sulfoxideexcreted. Coadministration of aspirin is contraindicated becauseit considerably reduces the sulfide blood levels. Carefulmonitoring of patients with a history of ulcers is recommended.Gastric bleeding, nausea, diarrhea, dizziness, andother adverse effects have been noted with sulindac, but witha lower frequency than with aspirin. Sulindac is recommendedfor RA, OA, and ankylosing spondylitis.
  • Biologische Aktivität Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo . Widely used anti-inflammatory agent.
Sulindac Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sulindac Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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38194-50-2, Sulindac Verwandte Suche:
  • (z)-5-fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1h-indene-3-ac
  • sulindacsulfoxide
  • (Z)-5-FLUORO-2-METHYL-1-[P-(METHYLSULFINYL)BENZYLIDENE]INDENE-3-ACETIC ACID
  • 5-FLUORO-2-METHYL-1Z-[[4(METHYLSILFUNYL)PHENYL]METHYLENE]-1H-INDENE-3-ACETIC ACID
  • AFLODAC
  • ALGOCETIL
  • AKOS NCG1-0019
  • (1Z)-5-FLUORO-2-METHYL-1-[[4-(METHYLSULFINYL)PHENYL]METHYLENE]-1H-INDENE-3-ACETIC ACID
  • LABOTEST-BB LT00772301
  • SULINDAC, USP
  • (1Z)-5-Fluoro-2-methyl-1-[(4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic Acid, MK-231, Aflodac, Algocetil, Sulinol, Sulreuma
  • 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-4-(methylsulfinyl)phenylmethylene-, (1Z)-
  • SULINDAC(RG)
  • NO-SULINDAC
  • Saldac
  • (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
  • Arthrobid
  • Arthroeine
  • Artribid
  • Citireuma:Clinoril
  • Clisundac
  • Imbaral
  • Reumofil
  • Sudac
  • Sulinol:S1ureuma
  • cis-5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1h-indene-3-ac
  • cis-sulindac
  • clinoril
  • Clusinol
  • mobilin
  • SULINOL
  • SULINDAC
  • SULREUMA
  • MK-231
  • 5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
  • cis-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidenyl]indene-3-acetic acid
  • Citireuma
  • Sulindac,(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
  • Sulindac (200 mg)
  • 2-[(1E)-5-fluoro-1-({4-[(R)-Methanesulfinyl]phenyl}Methylidene)-2-Methyl-1H-inden-3-yl]acetic acid
  • Sulindac(Clinoril)
  • ReuMyl
  • SULINDAC API
  • Sulindac E IsoMer
  • (Z)-2-(5-Fluoro-2-Methyl-1-(4-(Methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic acid
  • Sulindac SynonyMs (Z)-5-Fluoro-2-Methyl-1-[p-(Methylsulfinyl)benzylidene]indene-3-acetic acid
  • (Z)-2-(3-(4-(methylsulfinyl)benzylidene)-6-fluoro-2-methyl-3H-inden-1-yl)acetic acid
  • Sulindac Solution, 100ppm
  • {5-Fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
  • Sulindac,Clinoril,Imbaron,Sudac,Sulinol,Artribid,Sudac,Zulida,Lyndak.
  • Sulindac, 98%, a COX inhibitor
  • 1h-indene-3-aceticacid,5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methyle
  • Aclin
  • arthrocine
  • 38194-50-2
  • C20H17FO3S
  • Active Pharmaceutical Ingredients
  • Intermediates & Fine Chemicals