Carbimazol

Bezeichnung:Carbimazol

CAS-Nr22232-54-8

Englisch Name:Carbimazole

CBNumberCB3731303

SummenformelC7H10N2O2S

Molgewicht186.23

MOL-Datei22232-54-8.mol

Synonyma

Carbimazol

Carbimazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	124°C
Siedepunkt	240.4±23.0 °C(Predicted)
Dichte	1.2900 (rough estimate)
Brechungsindex	1.5400 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: soluble5mg/mL, clear (warmed)
Aggregatzustand	powder
pka	-1.70±0.20(Predicted)
Farbe	white to beige
Wasserlöslichkeit	Soluble in water, ethanol, chloroform and acetone. Sightly soluble in water.
Sensitive	Light Sensitive
Merck	14,1798
BRN	144339
InChIKey	CFOYWRHIYXMDOT-UHFFFAOYSA-N
CAS Datenbank	22232-54-8(CAS DataBase Reference)
NIST chemische Informationen	Carbimazole(22232-54-8)

Sicherheit

R-Sätze:	22-36-43
S-Sätze:	22-36/37/39
RIDADR	3335
WGK Germany	3
RTECS-Nr.	NJ2441000
HS Code	2933.29.9000

Gefahreninformationscode (GHS)

Carbimazole Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White Solid
Originator
Carbimazol,Cid Co.
Verwenden
Ethyl 3-methyl-2-thionoimidazoline-1-carboxylate is used as thyroid inhibitor.
Verwenden
Thionamide antithyroid drug.
Verwenden
Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.
Definition
ChEBI: A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Manufacturing Process
0.1 mol of 1-methyl-2-mercaptoglyoxaline is dissolved in the minimum quantity of pyridine at 0°C 0.1 mol of ethyl chloroformate is added drop wise with stirring. More pyridine is added, if necessary, to keep the mixture semi-fluid. The sludge is then placed in an ice bath for 30 minutes. The crystals are filtered off and washed firstly with a little ethanol and secondly with ethanol and water. The non-basic desired ethyl 3-methyl-2-thioimidazoline-1- carboxylate is the colourless needles having a melting point of 122°-123°C.
Therapeutic Function
Thyroid inhibitor
Clinical Use
Treatment of hyperthyroidism
Synthese
Carbimazole, the ethyl ester of 3-methyl-2-thioimidazolin-1-carboxylic acid (25.2.7), is synthesized by a simultaneous reaction of ethylenacetal of bromoacetaldehyde with methylamine and potassium isocyanate, forming 3-methyl-2-imidazolthione (25.2.6), which is further acylated at the nitrogen atom by ethyl chloroformiate, giving the desired product (25.2.7).
Veterinary Drugs and Treatments
Carbimazole (a pro-drug of methimazole) or methimazole are considered by most clinicians to be the agents of choice when using drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to methimazole.
Methimazole and therefore, carbimazole, may be useful for the prophylactic prevention of cisplatin-induced nephrotoxicity in dogs.
Stoffwechsel
Carbimazole is rapidly metabolised to thiamazole, which is concentrated in the thyroid gland. Over 90% of orally administered carbimazole is excreted in the urine as thiamazole or its metabolites. The remainder appears in faeces. There is 10% enterohepatic circulation. Thiamazole is metabolised, probably by the liver, and excreted in the urine. Less than 12% of a dose of thiamazole may be excreted as unchanged drug

Carbimazole Upstream-Materialien And Downstream Produkte

Carbimazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

22232-54-8, Carbimazole Verwandte Suche:

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