3-Nitrophenol

Bezeichnung:3-Nitrophenol

CAS-Nr554-84-7

Englisch Name:3-Nitrophenol

CBNumberCB3728637

SummenformelC6H5NO3

Molgewicht139.11

MOL-Datei554-84-7.mol

Synonyma

3-Nitrophenol

3-Nitrophenol physikalisch-chemischer Eigenschaften

Schmelzpunkt	96-98 °C (lit.)
Siedepunkt	194 °C/70 mmHg (lit.)
Dichte	1,49 g/cm³
Brechungsindex	1.5723 (estimate)
Flammpunkt	102°C
storage temp.	Store at +5°C to +30°C.
Löslichkeit	13.5g/l insoluble
Aggregatzustand	Crystalline Powder
pka	8.28(at 25℃)
Farbe	Yellow to brown
Säure-Base-Indikators(pH-Indikatoren)	6.6(colourless)-8.6(yellow/orange)
PH	6.6-8.6 (H2O, 20℃)
Wasserlöslichkeit	13.5 g/L (25 ºC)
maximale Wellenlänge (λmax)	570nm
Merck	14,6618
BRN	1907946
Major Application	Display device, semiconductor device, sensors, high voltage capacitors, energetic materials, electrolyte batteries, inks, correction fluid, detergent, leak detection method, lubricants, insecticide, food storage, inhibition of amyloidoses, detect bacterialinfection, drugs, material for evaluating dental caries activity
InChIKey	RTZZCYNQPHTPPL-UHFFFAOYSA-N
CAS Datenbank	554-84-7(CAS DataBase Reference)
NIST chemische Informationen	Phenol, 3-nitro-(554-84-7)
EPA chemische Informationen	m-Nitrophenol (554-84-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-38-41-36/37/38-33-20/21/22
S-Sätze:	26-36/37-45-36/37/39-22-28
RIDADR	UN 1663 6.1/PG 3
WGK Germany	3
RTECS-Nr.	SM1925000
F	8
Selbstentzündungstemperatur	400 °C
Hazard Note	Harmful/Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29089000
Giftige Stoffe Daten	554-84-7(Hazardous Substances Data)
Toxizität	LD50 orally in mice, rats: 1414, 933 mg/kg, K. C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972)

Gefahreninformationscode (GHS)

3-Nitrophenol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R41:Gefahr ernster Augenschäden.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R33:Gefahr kumulativer Wirkungen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
Chemische Eigenschaften
yellow to brown crystalline powder
Verwenden
3-Nitrophenol is a chemical reagent used in various organic syntheses. Used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors against epidermal growth factor receptor T790M mutation.
Verwenden
As indicator in 0.3% solution in 50% alcohol. pH: 6.8 colorless, 8.6 yellow.
Vorbereitung Methode
3-Nitroaniline is diazotized in aqueous sulfuric acid and then hydrolyzed by being added gradually to boiling dilute sulfuric acid. The crude product solidifies on cooling and is filtered off in 90 % yield.
Definition
ChEBI: A member of the class of 3-nitrophenols that is phenol in which one of the hydrogens that is meta to the hydroxy group has been replaced by a nitro group.
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 5117, 1995 DOI: 10.1016/0040-4039(95)00963-D
Allgemeine Beschreibung
Colorless to pale yellow crystalline solid. Sinks in and mixes with water.
Air & Water Reaktionen
Water insoluble.
Reaktivität anzeigen
3-Nitrophenol is a light-yellow, crystalline material, toxic and irritant. When heated to decomposition 3-Nitrophenol emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases.
Hazard
Toxic by ingestion.
Health Hazard
INHALATION: Inhalation or ingestion causes headaches, drowsiness, nausea, and blue color in lips, ears, and finger nails (cyanosis). EYES: Contact with eyes causes irritation. SKIN: Can be absorbed through intact skin to give same symptoms as for inhalation.
Brandgefahr
Special Hazards of Combustion Products: Dangerous toxic fumes of NO x
Sicherheitsprofil
Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic by skin contact. A skin and severe eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also other nitrophenol entries.
läuterung methode
Crystallise 3-nitrophenol from water, CHCl3, CS2, EtOH or pet ether (b 80-100o), and dry it under vacuum over P2O5 at room temperature. It can also be distilled at low pressure. The 4-nitrobenzoate had m 174o (from EtOH). [Beilstein 6 IV 1269.]

3-Nitrophenol Upstream-Materialien And Downstream Produkte

3-Nitrophenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

554-84-7, 3-Nitrophenol Verwandte Suche:

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