ATRIAL NATRIURETIC FACTOR (1-28) (RAT) Struktur

ATRIAL NATRIURETIC FACTOR (1-28) (RAT)

Bezeichnung:ATRIAL NATRIURETIC FACTOR (1-28) (RAT)

CAS-Nr88898-17-3

Englisch Name:ATRIAL NATRIURETIC FACTOR (1-28) (RAT)

CBNumberCB3670516

SummenformelC128H205N45O39S2

Molgewicht3062.41

MOL-Datei88898-17-3.mol

ATRIAL NATRIURETIC FACTOR (1-28) (RAT) physikalisch-chemischer Eigenschaften

Dichte	1.54±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	0.05 M acetic acid: 1 mg/mL, clear, colorless
Aggregatzustand	Solid
Farbe	White to off-white
Wasserlöslichkeit	Soluble to 1 mg/ml in water
Sequenz	H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH(Disulfide bridge: Cys7-Cys23)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10

ATRIAL NATRIURETIC FACTOR (1-28) (RAT) Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Atrial natriuretic peptide is the first cardiac hormone isolated from the atria with potent hypotensive and natriuretic/diuretic actions. It is a drug target for hypertension and cardiac/renal failure. The presence of a natriuretic factor in the rat heart was first reported in 1981; it was isolated in 1983 from the rat and human atria.
Verwenden
Atrial Natriuretic Peptide rat has been used:
- In the absorption test to confirm the specificity of the anti-NP antibodies.
- To study the effects of atrial natriuretic peptide (ANP) on renal water and sodium regulation in rats.
- To study the integrated biological effects of ANP on myocardial infarction using mice models.
Biochem/physiol Actions
ANP production is regulated by factors associated with developmental, hormonal and hemodynamic processes. Its secretion is stimulated by atrial wall stretch, and ischemia.
Clinical Use
28-peptide, vasodilator, that increases glomerular filtration and diuresis.
Clinical Use
The plasma ANP concentration is routinely measured to diagnose cardiac failure. The N-terminal fragment of proANP (NT-proANP) is also measured for diagnosis because of its longer half-life in plasma. Synthetic human ANP (Carperitide1 or Hanp) is used for the treatment of acute heart failure. Many kits for the measurement of plasma ANP are sold by various companies. Recently, ANP has been gradually replaced by BNP for the diagnosis and treatment of cardiac failure because of its immediate secretion in the earlier phase.
Lager
Store at -20°C
Structure and conformation
Human proANP consists of 126 aa residues with bioactive mature ANP at the C-terminus. Human ANP, or ANP99–126, consists of 28 aa residues with an intramolecular ring structure of 17 aa residues, as with other NPs1. Amphibians and bony fish also possess ANP, but birds, reptiles (except for turtles), cartilaginous fish, and cyclostomes do not. N-terminal truncated forms exist in the brain and an N-terminal elongated form named urodilatin is present in the kidney. The sequence identity is low in the prosegment. The mature ANP sequence is conserved (only one aa difference) in mammals, but is variable across different classes. Most ANPs of teleosts have an amidated C-terminus.

ATRIAL NATRIURETIC FACTOR (1-28) (RAT) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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