NT-3, human recombinant

NT-3, human recombinant Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Neurotrophin-3 (NT-3) is a neurotrophin that is involved in neurogenesis and neuronal plasticity, proliferation, differentiation, and survival.1,2,3 It is produced as a precursor protein composed of a signal peptide, a prodomain, and the mature NT-3 sequence, which is secreted from neurons after cleavage of the proprotein.2 NT-3 is expressed in the cerebellum and peripheral tissues such as the heart, spleen, and kidneys.4,5 It homodimerizes and induces neurotropic signaling mainly through tropomyosin-related kinase C (TrkC) and the p75 neurotrophin receptor (p75NTR), but it does signal through TrkA and TrkB to a lesser extent.1,2 NT-3 induces neurite outgrowth in chick embryonic peripheral sensory and sympathetic neurons in vitro.5 Conditional knockout of Ntf3, the gene encoding NT-3, in the brain induces learning deficits in a spatial memory task in mice.3 Hippocampal and prefrontal cortex levels of NT-3 are decreased in suicide victims.6 Cayman’s NT-3 (human, recombinant) protein can be used for binding assays. The protein was synthesized from a DNA sequence encoding the mature form of human NT-3 (Tyr139-Thr257) with an N-terminal translation-initiating methionine (Met1). The expressed protein consists of 120 amino acids, has a calculated molecular weight of 13.8 kDa, and a predicted N-terminus of Met1.WARNING This product is not for human or veterinary use.

NT-3, human recombinant Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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