2-Furoyl-LIGRLO-amide TFA

2-Furoyl-LIGRLO-amide TFA Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2]..

• in vivo

  Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3^-/- mice. But it decreases significantly the number of scratches in WT mice^[3].

  Animal Model:	Adult male (2/3-month-old) Trpv3-/- and WT mice[2]
  Dosage:	10 μg
  Administration:	Injected intradermally at the nape of the neck
  Result:	Was involved in PAR2- induced acute itch.

• IC 50

  PAR2

• Einzelnachweise

  [1] McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31. DOI:10.1124/jpet.103.064584
  [2] Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87. DOI:10.1096/fj.11-201004
  [3] Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol DOI:10.1016/j.jid.2020.01.012

2-Furoyl-LIGRLO-amide TFA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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