InSolution p38 MAP Kinase Inhibitor III - Calbiochem

InSolution p38 MAP Kinase Inhibitor III - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

• Allgemeine Beschreibung

  A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 380 nM for p38α). Shown to effectively suppress LPS-induced cytokine release in vitro (IC₅₀ = 160 nM for TNF-α release and 39 nM for IL-1β release, human PBMC) and in vivo (ED₅₀ = 1.33 mg/kg for TNF-α release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.

• Biochem/physiol Actions

  Cell permeable: yes

InSolution p38 MAP Kinase Inhibitor III - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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