Adrenocorticotropic hormone Struktur

α1-39-Corticotropin (Schwein)

Bezeichnung:α1-39-Corticotropin (Schwein)

CAS-Nr9061-27-2

Englisch Name:Adrenocorticotropic hormone

CBNumberCB3452071

SummenformelC210H314N56O57S

Molgewicht4567.14616

MOL-Datei9061-27-2.mol

Synonyma

α1-39-Corticotropin (Schwein)

α1-39-Corticotropin (Schwein) physikalisch-chemischer Eigenschaften

storage temp.	−20°C
Aggregatzustand	powder
InChIKey	XFBDTKGDXZDJAN-WODOTNDISA-N

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-40
S-Sätze:	22-36
WGK Germany	3

Gefahreninformationscode (GHS)

Adrenocorticotropic hormone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Indications
Adrenocorticotropic hormone (ACTH), or corticotropin, a peptide of 39 amino acids, is first synthesized as a larger precursor from which ACTH is derived by proteolytic cleavage. ACTH stimulates production of glucocorticoids from the adrenal cortex. Release of ACTH depends on diurnal rhythms with serum levels highest in the early morning. Secretion of this peptide also increases under stress. It is easier and less expensive to treat patients having adrenocortical insufficiency with glucocorticoid replacement therapy than it is to use ACTH. Therefore, use of ACTH (Acthar) is restricted to diagnosis; a shorter 24–amino acid analogue (Cosyntropin) is also used. Intravenous administration of ACTH should result in peak plasma levels of glucocorticoids within 30 to 60 minutes if the adrenal gland is functional. Prolonged administration of ACTH in a repository form, however, may be necessary to stimulate steroid production, because ACTH has long-term trophic effects on adrenal cells in addition to the rapid stimulation of steroid production. If the cause of steroid deficiency is at the level of the pituitary gland, ACTH should eventually stimulate steroid production.
Biologische Funktion
The main function of Adrenocorticotropic hormone (ACTH) is to regulate the glucocorticoid (steroid) hormone cortisol. Cortisol is released by the adrenal gland. It regulates blood pressure, blood sugar, the immune system, and the response to stress. This test can help find the causes of certain hormone problems
Health Hazard
Adrenocorticotropic Hormone (ACTH;Adrenocorticotropin; corticotropic hormone): (1)Maintenance of adrenal cortex;(2)Promotes secretion of steroids, oxidative phosphorylation in adrenal cortex;(3)Mobilizes and increases oxidation of free fatty acid in adipose tissue;(4)Increases gluconeogenesis in liver; increases cyclic adenosine monophosphate (AMP) in adrenal cortex;Decreases urea formation in liver.
Biochem/physiol Actions
Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.
Producing and consuming organs
The anterior pituitary produces ACTH. It is considered a tropic hormone. Tropic hormones indirectly affect target cells by first stimulating other endocrine glands. Corticotropin-releasing hormone (CRH) is released from the hypothalamus, which stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH). ACTH then acts on its target organ, the adrenal cortex.

α1-39-Corticotropin (Schwein) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

9061-27-2, Adrenocorticotropic hormone Verwandte Suche:

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