10-Deacetylbaccatin III

Bezeichnung:10-Deacetylbaccatin III

CAS-Nr32981-86-5

Englisch Name:10-Deacetylbaccatin III

CBNumberCB3447497

SummenformelC29H36O10

Molgewicht544.59

MOL-Datei32981-86-5.mol

10-Deacetylbaccatin III physikalisch-chemischer Eigenschaften

Schmelzpunkt	231-236 °C
Siedepunkt	717℃
alpha	-44.5 º (c=1, methanol 25 ºC)
Dichte	1.2007 (rough estimate)
Brechungsindex	1.5376 (estimate)
Flammpunkt	>110°(230°F)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)
Aggregatzustand	Powder
pka	11.50±0.70(Predicted)
Farbe	white
Wasserlöslichkeit	INSOLUBLE
InChIKey	YWLXLRUDGLRYDR-IYNRKYTHSA-N
SMILES	O1C[C@@]2(OC(C)=O)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](O)C4)[C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@@]12[H]
LogP	0.156 (est)
CAS Datenbank	32981-86-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	45-38-36/37/39-28A-24/25
RIDADR	1544
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III
HS Code	29329990

Gefahreninformationscode (GHS)

10-Deacetylbaccatin III Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
10-Deacetylbaccatin III is White Solid
Verwenden
10-Deacetylbaccatin III is a intermediate in the synthesis of Taxol and derivatives
Verwenden
10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives.
Verwenden
10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the le
Definition
ChEBI: 10-deacetylbaccatin III is a tetracyclic diterpenoid and a secondary alpha-hydroxy ketone. It is functionally related to a baccatin III.
Allgemeine Beschreibung
10-Deacetylbaccatin III, also known as Paclitaxel Impurity 19, is an impurity of Paclitaxel. Paclitaxel is a chemotherapy drug. Chemotherapy is a treatment that destroys cancer cells using anti-cancer drugs. Paclitaxel is the non-branded name of the drug, but you may hear it called by one of its brand names such as Taxol. Some people are given a drug called nab-paclitaxel (Abraxane).
Biologische Aktivität
10-dab (also known as 10-deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the pacific yew tree taxus brevifolia as well as other species of the genus taxus. due to the low availability of taxol from its natural sources, 10-dab is used as a raw material for the preparation of taxol and its derivatives. being easily extracted from the annual cute of the yew leaves, 10-dab has a very folded chemical structure with the α hydroxyl group hindered at c-13 easily to form a hydrogen bond with the 4α acetyl group.f. gueritte-voegelein, v. senilh, b. david, d. guenard and p. potier. chemical studies of 10-deacetyl baccatin iii hemisynthesis of taxol derivatives. tetrahedron 1986; 42(16): 4451-4460

10-Deacetylbaccatin III Upstream-Materialien And Downstream Produkte

10-Deacetylbaccatin III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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