4-Brombenzonitril

Bezeichnung:4-Brombenzonitril

CAS-Nr623-00-7

Englisch Name:4-Bromobenzonitrile

CBNumberCB3423145

SummenformelC7H4BrN

Molgewicht182.02

MOL-Datei623-00-7.mol

Synonyma

4-Brombenzonitril

4-Brombenzonitril physikalisch-chemischer Eigenschaften

Schmelzpunkt	110-115 °C(lit.)
Siedepunkt	235-237 °C(lit.)
Dichte	1,562 g/cm³
Brechungsindex	1.5999 (estimate)
Flammpunkt	130°C
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	0.2g/l
Aggregatzustand	Powder or Flakes
Farbe	White to light yellow or flakes
Wasserlöslichkeit	Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether.
BRN	2041518
InChIKey	HQSCPPCMBMFJJN-UHFFFAOYSA-N
LogP	2.3 at 22.5℃ and pH7
CAS Datenbank	623-00-7(CAS DataBase Reference)
NIST chemische Informationen	4-Bromobenzoic acid nitrile(623-00-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,Xi
R-Sätze:	22-36/37/38-20/21/22
S-Sätze:	61-36/37/39-26-24/25
RIDADR	UN 3439 6.1/PG 3
WGK Germany	2
RTECS-Nr.	DI2460000
Hazard Note	Toxic/Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29269095

Gefahreninformationscode (GHS)

4-Bromobenzonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
4-Bromobenzonitrile is white to light yellow powder or flakes
Verwenden
4- Bromobenzonitrile is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceu ticals and other organic chemicals,
Verwenden
4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.
Synthesis Reference(s)
Tetrahedron Letters, 27, p. 1925, 1986 DOI: 10.1016/S0040-4039(00)84413-5
Synthese
To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6 (0.6 mmol,220 mg), K2CO3 (1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMF were added and the mixture was stirred for appropriate reaction time at 120 ℃ under argon atmosphere. The progress of the reaction was monitored by GC analysis. After completion of the reaction, the reaction mixture was washed with 5 mL water, and the crude product was isolated using dichloromethane (5× 1 mL). Organic extracts were combined, evaporated, and purified by flash chromatography using hexane/EtOAc to give 4-Bromobenzonitrile.

4-Bromobenzonitrile Upstream-Materialien And Downstream Produkte

4-Brombenzonitril Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

623-00-7, 4-Bromobenzonitrile Verwandte Suche:

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