N-OMEGA-PROPYL-L-ARGININE

N-OMEGA-PROPYL-L-ARGININE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  N^ω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). N^ω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a K_i value of 57 nM. The K_i values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 μM, respectively. N^ω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.

• Chemische Eigenschaften

  Off-White Solid

• Verwenden

  A highly selective competitive inhibitor and inactivator of all three isoforms of NOS.

• Verwenden

  Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).

• Biologische Aktivität

  Highly selective and potent inhibitor of nNOS (K i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo .

• Lager

  room temperature (desiccate)

N-OMEGA-PROPYL-L-ARGININE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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