Triisopropylsilyl chloride

Bezeichnung:Triisopropylsilyl chloride

CAS-Nr13154-24-0

Englisch Name:Triisopropylsilyl chloride

CBNumberCB3405310

SummenformelC9H21ClSi

Molgewicht192.8

MOL-Datei13154-24-0.mol

Triisopropylsilyl chloride physikalisch-chemischer Eigenschaften

Siedepunkt	198 °C739 mm Hg(lit.)
Dichte	0.901 g/mL at 25 °C(lit.)
Dampfdruck	1.16 mm Hg ( 20 °C)
Brechungsindex	n20/D 1.452(lit.)
Flammpunkt	145 °F
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Sol THF, DMF, CH2Cl2.
Aggregatzustand	liquid
Wichte	0.903
Farbe	colorless
Wasserlöslichkeit	Miscible with water.
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
BRN	1737446
InChIKey	KQIADDMXRMTWHZ-UHFFFAOYSA-N
CAS Datenbank	13154-24-0(CAS DataBase Reference)
NIST chemische Informationen	Triisopropylsilyl chloride(13154-24-0)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-27-36/37/39-36/39
RIDADR	UN 2987 8/PG 2
WGK Germany	3
F	10-21
Hazard Note	Corrosive
TSCA	No
HazardClass	8
PackingGroup	II
HS Code	29319090

Gefahreninformationscode (GHS)

Triisopropylsilyl chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/39:Bei der Arbeit geeignete Schutzkleidung und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Triisopropyl chlorosilane is an important sterically hindered organosilicon protective agent, which is mainly used to protect various types of hydroxyl groups, especially in polyfunctional hydroxyl compounds, which can be selectively protected and deprotected. It is very important to synthesize nucleosides, nucleotides and carbohydrates. Triisopropylchlorosilane is a good hydroxyl protecting agent, and its silanization reaction is carried out in a slight excess of imidazole solution. The acid hydrolytic stability of the protected intermediate is between TBDMS and TBDPS and the alkaline hydrolytic stability is higher than the former two.
Chemische Eigenschaften
Triisopropylsilyl chloride is colorless clear liquid
Physikalische Eigenschaften
bp 198 °C/739 mmHg; d 0.901 g cm?3.
Verwenden
Triisopropylsilyl chloride is used as a catalyst in the preparation of (silyloxy)cyclobutene derivatives. Also used in the addition of diethylzinc to N-diphenylphosphinoyl imines.
Verwenden
Chlorotriisopropylsilane is used as a silylating agent in neucleotide synthesis. It is used as an intermediate in the manufacture of chemical substances such as pharmaceuticals and in organic synthesis.
Verwenden
Triisopropylsilyl Chloride is a valuable reagent for hydroxy protecting group; formation of triisopropylsilyl ynol ethers;N-protection of pyrroles; prevents chelation with Grignard reagents, including but not limited to Formation of Silyl Ynol Ethers, N-Protection of Pyrroles, Prevention of Chelation in Grignard Reactions, Protection of Terminal Alkynes, Protection of Pyrroles, Indoles, and Other Heterocycles,Preparation of “Supersilylating” Agents,Reactions with Hydrazine, Reactions with Other Nucleophiles etc.
synthetische
There are two main methods for synthesizing triisopropyl chlorosilane. One is to use triisopropyl silane as a raw material, and hydrochloric acid and other reagents are used to chlorinate the hydrogen on the silicon. Another method uses silicon tetrachloride as raw material, and reacts with isopropyl lithium to obtain triisopropyl chlorosilane.
Application
Triisopropyl chlorosilane is mainly used as a basic intermediate in the synthesis of organic silicon materials and a blocking agent for silicone oil or silicone rubber. These triisopropylchlorosilanes can be used as raw materials for preparing functional silanes or silane coupling agents. In the reaction with organometallic compounds, the chlorine atoms of triisopropylchlorosilane are replaced by corresponding organic groups to form organochlorosilanes or organofunctional silanes.
Triisopropyl chlorosilane is mainly used in the production of aminosilane and methacryloxysilane, and can also be used as a rubber processing additive to couple inorganic fillers in various halogenated rubbers, such as neoprene rubber, chlorobutyl rubber , chlorosulfonated polyethylene and other halogenated rubbers. The existence of triisopropylchlorosilane can greatly improve various physical and mechanical properties of composites. Triisopropylchlorosilane can also be used to prepare antifungal and deodorant finishes with special bactericidal, deodorant, antistatic and surface-active properties.

Triisopropylsilyl chloride Upstream-Materialien And Downstream Produkte

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