4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  130636-61-2

  

  304897-49-2

  Tert-butyl 4-(4-nitrobenzyl)piperazine-1-carboxylate (1.100 g, 3.423 mmol) was added to a solvent mixture of tetrahydrofuran solution (20 mL) of ammonium chloride (0.915 g, 17.114 mmol) and zinc powder (1.119 g, 17.114 mmol) with water (20 mL) as starting material, and the reaction was stirred for 12 h at room temperature. . Upon completion of the reaction, the reaction mixture was filtered to remove solid impurities. Water was added to the filtrate and subsequently extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting product, tert-butyl 4-(4-aminobenzyl)piperazine-1-carboxylate (0.900 g, 90.2% yield), was a yellow solid and could be used in subsequent reactions without further purification.

• Einzelnachweise

  [1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
  [2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
  [3] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 1492; 1493; 1494
  [4] Patent: WO2016/146220, 2016, A1. Location in patent: Page/Page column 26; 27
  [5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Upstream-Materialien And Downstream Produkte

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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