PINOCEMBRIN

Bezeichnung:PINOCEMBRIN

CAS-Nr480-39-7

Englisch Name:PINOCEMBRIN

CBNumberCB3378883

SummenformelC15H12O4

Molgewicht256.25

MOL-Datei480-39-7.mol

PINOCEMBRIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	202 °C
Siedepunkt	511.1±50.0 °C(Predicted)
Dichte	1.386±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	Soluble in ethanol and methan
Aggregatzustand	powder
pka	7.50±0.40(Predicted)
Farbe	White
LogP	3.225 (est)
EPA chemische Informationen	4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)- (480-39-7)

Sicherheit

S-Sätze:	24/25
HS Code	29329990

Gefahreninformationscode (GHS)

PINOCEMBRIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Pinocembrin is a flavonoid that has been found in Eucalyptus, and has diverse biological activities. It induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells when used at a concentration of 200 μM. Pinocembrin (5 mg/kg) reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced intracerebral hemorrhage (ICH). It prevents increases in plasma and kidney malondialdehyde (MDA) levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy. Pinocembrin (20 and 50 mg/kg) reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury.
Chemische Eigenschaften
Solid
Verwenden
Pinocembrin is a flavanoid with antioxidant activity found in damiana, honey, and propolis. Recent studies show that Pinocembrin maybe be a therapeutic option in reducing cerebral ischemia/reperfusion injury as a result of its anti-oxidative and anti-apoptotic effects. Pinocembrin displayed neuroprotective effects in glutamate injury model partly by inhibiting p53 expression causing a lower Bax-Bcl-2 ratio and by inhibiting the release of cytochrome c.
Definition
ChEBI: Pinocembrin is a dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. It has a role as an antioxidant, an antineoplastic agent, a vasodilator agent, a neuroprotective agent and a metabolite. It is a dihydroxyflavanone and a (2S)-flavan-4-one.

PINOCEMBRIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

480-39-7, PINOCEMBRIN Verwandte Suche:

Send Inquriy