Salidroside

Bezeichnung:Salidroside

CAS-Nr10338-51-9

Englisch Name:Salidroside

CBNumberCB3353251

SummenformelC14H20O7

Molgewicht300.3

MOL-Datei10338-51-9.mol

Salidroside physikalisch-chemischer Eigenschaften

Schmelzpunkt	159～160℃
Siedepunkt	549.5±50.0 °C(Predicted)
Dichte	1.46±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Methanol (Slightly), Pyridine (Slightly)
pka	9.98±0.15(Predicted)
Aggregatzustand	Solid
Farbe	Off-White
Optische Aktivität	[α]/D -29±2°, c = 0.5 in methanol
InChI	InChI=1/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/s3
InChIKey	ILRCGYURZSFMEG-RKQHYHRCSA-N
SMILES	[C@H]1(OCCC2C=CC(O)=CC=2)[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O \|&1:0,11,13,14,16,r\|
LogP	-1.230 (est)
CAS Datenbank	10338-51-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	LZ5901900
HS Code	29389090

Gefahreninformationscode (GHS)

Salidroside Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White to off-white solid
Verwenden
Salidroside is a phenylpropanoid glycoside that exhibits a wide range of pharmacological effects. This include protective effects against neuronal death which can be applied to the treatment of Alzheimer’s disease. Cardioprotecticve, countering oxidative stress in cardiac related malignanied=v
Definition
ChEBI: Salidroside is a glycoside.
benefits
Salidroside is the main active ingredient extracted from Rhodiola rosea and has antioxidant, anti-inflammatory, neuroprotective activities, activation of tumour suppressor kinases and other activities. It can be used in the treatment of neurological disorders (e.g. Alzheimer's disease, Parkinson's disease, traumatic brain injury, stroke, depression), cardiovascular diseases, tumours and other diseases. It is also used in the treatment of ulcerative colitis. In innate immunity, upregulated TREM1 pyroptosis-related proteins in inflamed colons were inhibited by salidroside administration further experiments in vitro showed that salidroside suppressed LPS/ATP-induced bone marrow-derived macrophages (BMDMs) pyroptosis evident by decline LDH IL-1β release as well as protein level NLRP3, caspase-1, GSDMD p30.
Mechanism of action
The salidroside present in R. rosea exerts its antistress, adaptogenic, and anti-depressive activity through stimulation of neuropeptide-Y with concomitant lower levels of HSP-72 (heat shock protein) release in brain microglial cells, ultimately modulating the HPA axis stress response. Salidroside could restore the balance of Th17/Treg cells, disrupted upon exposure to ischemia, thereby maintaining the peripheral neuron's stability after ischemia. Another neuroprotection mechanism by salidroside is maintaining monoamine neurotransmitters in the dopaminergic system. Monoamine oxidase (MAO) is an enzyme rich in the striatum and hypothalamus that could catalyze the oxidation of monoamines, such as dopamine, serotonin, adrenaline, non-adrenaline, and histamine[1-2].
Einzelnachweise
[1] Mukherjee, Dhrubojyoti . "Role of Stress in Diseases and Its Remedial Approach by Herbal and Natural Products in Stress-Related Disease Management." 2018.
[2] Jingxuan Han. "Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases." Frontiers in Pharmacology (2022): 974775.

Salidroside Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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