4-Nonylphenylboronic acid

Bezeichnung:4-Nonylphenylboronic acid

CAS-Nr256383-45-6

Englisch Name:4-Nonylphenylboronic acid

CBNumberCB3346668

SummenformelC15H25BO2

Molgewicht248.17

MOL-Datei256383-45-6.mol

4-Nonylphenylboronic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	82-85°C
Siedepunkt	385.3±35.0 °C(Predicted)
Dichte	0.97±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	Soluble in DMSO (up to 30 mg/ml)
Aggregatzustand	solid
pka	8.72±0.16(Predicted)
Farbe	White
Wasserlöslichkeit	Insoluble in water.
BRN	8215118
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS Datenbank	256383-45-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
Hazard Note	Irritant
HS Code	2931900090

Gefahreninformationscode (GHS)

4-Nonylphenylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Nonylbenzeneboronic acid (CAS 256383-45-6) is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes 2-arachidonoyl-glycerol), IC50=7.9 μM.1
Verwenden
4-n-Nonylbenzeneboronic acid is a potent inhibitor of fatty acid amide hydrolase. It is also able to inhibit monoacylglycerol lipase (MAGL), which hydrolyzes 2-arachidonoyl glycerol (2-AG).
in vitro
4-(n-nonyl) benzeneboronic acid was synthezed as a potent inhibitor of faah, with an ic50 of 9.1 nm. 4-(n-nonyl) benzeneboronic acid was also found to be able to inhibit magl, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. moreover, it was found that as the most potent para-substituted compound, 4-(n-nonyl) benzeneboronic acid showed rather high pka of 9.1. in addition, the molecular docking was utilized to gain insight on the faah binding mode of 4-(n-nonyl) benzeneboronic acid and a putative binding mode was observed [1].
IC 50
9.1 nm
Einzelnachweise
1) Minkkila?et al.?(2008),?Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase; J. Med. Chem.,?51?7057

4-Nonylphenylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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