H-8 DIHYDROCHLORIDE

H-8 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Beschreibung

  The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with K_i values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC₅₀ values of 47 and 6.2 μM, respectively.

• Chemische Eigenschaften

  white to off-white crystalline solid

• Verwenden

  Active inhibitor of cyclic-nucleotide-dependent protein kinases.

• Biochem/physiol Actions

  cAMP and cGMP-dependent protein kinase inhibitor.

H-8 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(75)Suppliers

113276-94-1, H-8 DIHYDROCHLORIDE Verwandte Suche: