DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE)

Bezeichnung:DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE)

CAS-Nr85272-31-7

Englisch Name:DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE)

CBNumberCB3337556

SummenformelC10H18F6O6S2Si

Molgewicht440.45

MOL-Datei85272-31-7.mol

DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE) physikalisch-chemischer Eigenschaften

Siedepunkt	73-75 °C/0.35 mmHg (lit.)
Dichte	1.352 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.398(lit.)
Flammpunkt	195 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	sol most common organic solvents.
Aggregatzustand	Oil
Farbe	Clear Pale Yellow
Wichte	1.358
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
BRN	3569211
Stabilität	Moisture Sensitive
InChIKey	HUHKPYLEVGCJTG-UHFFFAOYSA-N
CAS Datenbank	85272-31-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45
RIDADR	UN 3265 8/PG 2
WGK Germany	3
F	10-21
Hazard Note	Corrosive
TSCA	No
HazardClass	8
PackingGroup	III
HS Code	29319090

Gefahreninformationscode (GHS)

DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Colorless to yellow liquid
Physikalische Eigenschaften
bp 73–75°C/0.35 mmHg; d 1.208 g cm?3.
Verwenden
Protecting group reagent for 1,3-diols used recently in a synthesis of N-homoceramides. Also used for selective α-galactosylation in the synthesis of α-galactosyl ceramides.
Verwenden
Di-t-butylsilyl bis(trifluoromethanesulfonate) is a reagent for the selective protection of polyhydroxy compounds. This reagent reacts with 1,2-, 1,3-, and 1,4-diols under mild conditions to give the corresponding dialkylsilylene derivatives in high yield (0–50°C, 79–96%). Deprotection is conveniently achieved by using aqueous hydrofluoric acid in acetonitrile (eq 1).
Unlike di-t-butyldichlorosilane, this reagent reacts with hindered alcohols. Even pinacol reacts to give the silylene derivative (100°C, 24 h, 70%). Di-t-butylsilylene derivatives of 1,2-diols are more reactive than those of 1,3- and 1,4-diols and undergo rapid hydrolysis (5 min) in THF/H2O at pH 10, while the 1,3- and 1,4- derivatives are unaffected at pH 4–10 (22°C) for several hours. This protecting group is stable under the conditions of PDC oxidation of alcohols (CH2Cl2, 25?C, 27 h) and tosylation of alcohols (pyridine, 25°C, 27 h).
The reagent has seen limited use for the protection of alcohols but has been used to protect nucleosides (eq 2).The procedure consists of sequential addition of the ditriflate and triethylamine to the nucleoside in DMF. The choice of solvent is critical.
synthetische
by the treatment of di-t-butylchlorosilane with trifluoromethanesulfonic acid, followed by distillation (71% yield).

DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Upstream-Materialien And Downstream Produkte

DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

85272-31-7, DI-TERT-BUTYLSILYL BIS(TRIFLUOROMETHANESULFONATE) Verwandte Suche:

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