Methylamino-PEG4-acid

Methylamino-PEG4-acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Methylamino-PEG4-acid HCl salt is a PEG linker containing a carboxylic acid with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

• Verwenden

  Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

• IC 50

  PEGs

• Einzelnachweise

  [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methylamino-PEG4-acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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