Nadifloxacin

Bezeichnung:Nadifloxacin

CAS-Nr124858-35-1

Englisch Name:Nadifloxacin

CBNumberCB3301560

SummenformelC19H21FN2O4

Molgewicht360.38

MOL-Datei124858-35-1.mol

Nadifloxacin physikalisch-chemischer Eigenschaften

Schmelzpunkt	245-2470C (dec)
Siedepunkt	624.9±55.0 °C(Predicted)
Dichte	1.46±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly), Methanol (Sparingly, Heated)
Aggregatzustand	White to yellow crystalline solid.
pka	5.55±0.40(Predicted)
Farbe	White to Off-White
Merck	14,6345
InChI	InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
InChIKey	JYJTVFIEFKZWCJ-UHFFFAOYSA-N
SMILES	C12=CC(F)=C(N3CCC(O)CC3)C3=C1N(C(C)CC3)C=C(C(O)=O)C2=O
CAS Datenbank	124858-35-1(CAS DataBase Reference)

Sicherheit

HS Code	2933.99.7500
Toxizität	LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto)

Gefahreninformationscode (GHS)

Nadifloxacin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Nadifloxacin, one of the three new fluoroquinolone antibiotics launched in 1993 is indicated for topical treatment of acne vulgaris and other skin infections. Nadifloxacin has a potent and broad spectrum of activity against aerobic Gram-positive and -negative bacteria and against anaerobic bacteria. It produces significant improvement in patients with Propionibacterium acnes infection and does not appear to cause cross-resistance to other antibiotic agents. Its potent antimicrobial activity has also been demonstrated in the Pseudomonas aeruginosa burn wound infection model in mice. Nadifloxacin exerts its antibiotic activity by inhibiting the formation of supercoiled DNA by DNA gyrase.
Chemische Eigenschaften
Off-White Crystalline Solid
Originator
Otsuka (Japan)
Verwenden
Nadifloxacin is a topical fluorinated quinolone antibacterial used to treat skin conditions such as acne and other dermal infections caused by bacteria. This drug belongs to a class of calcium salt of polyacrylic acid crosslinked with divinyl glycol with minimal AEs.
Definition
ChEBI: Nadifloxacin is a pyridoquinoline, a hydroxypiperidine, a heteroarylpiperidine and a quinolone antibiotic. It has a role as an antibacterial drug. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.
Trademarks
Acuatim
Pharmazeutische Anwendungen
A lipophilic tricyclic fluorobenzoquinoline with a 4- hydroxylpiperinyl moiety at the C-8 position, formulated as a cream for topical use. It is active against many Grampositive bacteria involved in skin infections, including Propionibacterium acnes (MIC 0.25–2.0 mg/L), and Staph. aureus (MIC 0.015–2 mg/L). It appears to inhibit the generation of reactive oxygen species by neutrophils. The sodium salt is used as a 1% cream for use in acne vulgaris and cutaneous staphylococcal infections.

Nadifloxacin Upstream-Materialien And Downstream Produkte

Nadifloxacin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

124858-35-1, Nadifloxacin Verwandte Suche:

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