C-Peptide EIA Kit

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H290：Kann gegenüber Metallen korrosiv sein.

• Sicherheit

  P234：Nur im Originalbehälter aufbewahren.

  P390：Verschüttete Mengen aufnehmen, um Materialschäden zu vermeiden.

C-Peptide EIA Kit Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  For research use only. Not for use in diagnostic procedures.
  Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

• Allgemeine Beschreibung

  The C-Peptide Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting C-Peptide peptide based on the principle of Competitive Enzyme Immunoassay. EIA-CPE-1 only detects C-peptide, not Insulin A or B chain.

• Biochem/physiol Actions

  C-peptide inhibits endothelial dysfunction under high glucose conditions via inhibition of nuclear factor-κB (NF-κB) pathway. Experimental studies suggest that prolonged dosage of physiological concentration of C-peptide to type 1 diabetes patients minimizes diabetes-induced complications, such as glomerular hypertrophy and mesangial matrix expansion by interrupting transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNFα) signaling pathway. C-peptide reduces diabetes-induced glomerular hyperfiltration by contraction of the afferent arteriole, dilation of the efferent arteriole, and by inhibition of tubular reabsorption. C-Peptide also plays a crucial role in renal pathophysiology. C-peptide binds to a cell surface receptor that is likely to be G-protein coupled. This interaction stimulates various cellular functions such as increasing intracellular Ca2+ concentration, enhancing PI3-K (phosphoinositide 3-kinase) activity, increased endothelial nitric oxide synthase (eNOS) transcription, and activation of the Na+/K+ ATPase and mitogen-activated protein kinase (MAPK) signaling pathway.

C-Peptide EIA Kit Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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