Anti-COG6 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biologische Aktivität
The conserved oligomeric Golgi complex 6 (COG6) subunit is associated with the trafficking intermediates th at carry Golgi glycosyltransferases. This protein facilitates the interaction of COG complex with the target membrane (t-SNARE) syntaxin 6. COG6-lacking cells exhibit reduced steady-state levels of syntaxin 6 and attenuated endosome-to-trans-Golgi network (TGN) retrograde trafficking. Inadequacy of COG6 leads to a combined N- and O-glycosylation deficiency of the congenital disorders of glycosylation known as CDG-IIL (COG6-CDG).
