DBCO-amine Struktur

DBCO-amine

Bezeichnung:DBCO-amine

CAS-Nr1255942-06-3

Englisch Name:DBCO-amine

CBNumberCB32730210

SummenformelC18H16N2O

Molgewicht276.33

MOL-Datei1255942-06-3.mol

DBCO-amine physikalisch-chemischer Eigenschaften

Schmelzpunkt	86-96°C
Siedepunkt	549.9±50.0 °C(Predicted)
Dichte	1.25±0.1 g/cm3(Predicted)
storage temp.	-20°C
pka	8.81±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Yellow to Orange
InChI	InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
InChIKey	PQFQVUMDOWUGMK-CHMOPDDRSA-N
SMILES	C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCN

Sicherheit

WGK Germany	3
HS Code	29339900

Gefahreninformationscode (GHS)

DBCO-amine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
DBCO-amine is a simple building block containing a DBCO moiety and will add minimal spacer to the modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Verwenden
Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.
Verwenden
DBCO-Amine was useful for the study of labelled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy.
Properties and Applications
DBCO-amine is an aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition (SPAAC, also known as “copper-free click chemistry”). The DBCO moiety reacts selectively with azides via SPAAC to form stable triazole linkages. The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents. It recommends dimethylsulfoxide (DMSO), N, N’-dimethylformamide (DMF), or N, N’-dimethylacetamide (DMAC) as solvents for this product. DBCO-amine is relatively insensitive to bases and can be used in the presence of aqueous bases. This product is acid-sensitive. It should not be subjected to pH <5 during reaction or workup. The product should always be stored at -20°C when not in use.

DBCO-amine Upstream-Materialien And Downstream Produkte

DBCO-amine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1255942-06-3, DBCO-amine Verwandte Suche:

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