beta-Cyclodextrin hydrate

Bezeichnung:beta-Cyclodextrin hydrate

CAS-Nr68168-23-0

Englisch Name:beta-Cyclodextrin hydrate

CBNumberCB3270383

SummenformelC42H70O35

Molgewicht1134.98

MOL-Datei68168-23-0.mol

beta-Cyclodextrin hydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	>260 °C (dec.)(lit.)
alpha	161 º (c=1, H2O 25 ºC)
storage temp.	Refrigerator
Löslichkeit	Water (Slightly)
Aggregatzustand	Crystalline Powder
Farbe	White
Optische Aktivität	[α]20/D +142°, c = 1 in H2O (Dry basis)
Wasserlöslichkeit	18.5 g/L (25 ºC)
Merck	14,2718
BRN	5915513

Sicherheit

S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	GU2293000
TSCA	Yes
HS Code	35051000

beta-Cyclodextrin hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
β-Cyclodextrin (β-CD) is a cyclic oligosaccharide that contains seven D-(+)-glucopyranose units and has been used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH₂ groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.
Chemische Eigenschaften
white crystalline powder
Verwenden
beta-Cyclodextrin hydrate forms clathrates. Produces a water-soluble complex with dansyl chloride for the fluorescent labeling of proteins. It is used in pharmaceutical research, as pharmaceutical intermediates and also as chemical reagents.
Allgemeine Beschreibung
β-cyclodextrin (β-CD), a well-known macrocyclic oligosaccharide member of the CD family, is composed of seven D-glucose units connected via α(1→4) glycosidic bonds. Its ability to form several inclusion complexes with organic as well as inorganic compounds makes it a potential candidate in solid and solution state determinations.
läuterung methode
Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.]

beta-Cyclodextrin hydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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