8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one is a reactant in the preparation of benzo[7]annulen-7-amines with GluN2B affinity and selectivity.

• Synthese

  

  24790-66-7

  

  37949-03-4

  The general procedure for the synthesis of 8,9-dihydro-5H-benzo[7]roten-7(6H)-ones from the compound (CAS:24790-66-7) was as follows: first, 3 5,6,8,9-tetrahydro-benzocyclohepten-7-one (compound of formula II) was prepared. A mixture of isomers of dimethyl 7-oxo-5,6,8,9-tetrahydrobenzocycloheptene-6,8-dicarboxylate (80 g, obtained according to Preparation 2) was dissolved in a mixture of aqueous 3M sulfuric acid (300 mL) and acetonitrile (50 mL) under argon protection and refluxed overnight. Upon completion of the reaction, the mixture was diluted with ether, neutralized with 2M aqueous sodium hydroxide solution (3 x 300 mL), subsequently dried with magnesium sulfate and evaporated to dryness. The residue was distilled at 97-98 °C, 0.4-0.5 Torr to give colorless crystals (26.1 g, 84% yield, α,α'-dibromo-o xylene). The melting point of the product was 43-44 °C. The 1H-NMR (CDCl3) data were as follows: 7.23 (m, 4H, aromatic hydrogen); 2.91 (m, 2H, hydrogen in the C(6) and C(8) positions); 2.62 (m, 2H, hydrogen in the C(5) and C(9) positions).

• Einzelnachweise

  [1] Patent: US2010/69504, 2010, A1. Location in patent: Page/Page column 5
  [2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 23, p. 6638 - 6646
  [3] Patent: WO2008/83367, 2008, A2. Location in patent: Page/Page column 132-133
  [4] Patent: WO2010/5876, 2010, A2. Location in patent: Page/Page column 55-56
  [5] Drugs of the Future, 2018, vol. 43, # 9, p. 645 - 653

8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one Upstream-Materialien And Downstream Produkte

8,9-Dihydro-5H-benzo[7]annulen-7(6H)-one Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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