1,1,1,3,3,3-Hexafluorpropan-2-ol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H361：Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen.

  H373：Kann die Organe schädigen bei längerer oder wiederholter Exposition.

• Sicherheit

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

1,1,1,3,3,3-Hexafluoro-2-propanol Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
  R34:Verursacht Verätzungen.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

• Beschreibung

  1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is aclear, colorless, oily, combustible liquid. Odor is describedasaromatic. Molecular weight = 1 68.04; Specific grav-ity = 1.596 .at 20℃; Freezing/Melting point= -4℃;Boiling point = 59℃at 760 mmHg; V apor pressure:556 mmHg at 51℃; 1468 mmHg at 75℃; Flash point: .>93℃. Hazard Identification (based on NFPA-704 MRating System): Health 3; Flammability 0; Reactivity 0.W ater soluble; solubility=≥100 mg/mL at 20℃.

• Chemische Eigenschaften

  Colorless liquid

• Chemische Eigenschaften

  1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.

• Verwenden

  It is used as a polar solvent and exhibits strong hydrogen bonding properties.It dissolves substances that are hydrogen-bond acceptors, such as amides, ethers and a wide range of polymers, including those that are not soluble in the most common organic solvents.

• Verwenden

  1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.

• Verwenden

  Hexafluoroisopropanol is used to produce high-end chemicals, such as fluorinated surfactants, fluorinated emulsifier and fluorinated medicine, etc. HFIP is used as a solvent or cleaner in electronic industry.

• Verwenden

  Usually used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.

• Definition

  ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.

• Allgemeine Beschreibung

  1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.

• Air & Water Reaktionen

  Water soluble.

• Reaktivität anzeigen

  1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.

• Brandgefahr

  1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.

• mögliche Exposition

  A specialty solvent for some poly mers; a lavatory reagent.

• Erste Hilfe

  Eyes: Check the victim for contact lenses andremove. Flush victim's eyes with water or normal salinesolution for 20- 30 min, occasionally lifting lower andupper eyelids. Remove contaminated clothing and shoes.Get medical attention immediately. Do not put any oint-ments，oils， or medication in the victim's eyes withoutspecific instructions from a physician. Immediately trans-port the victim after flushing eyes to a hospital even ifno symptoms (such as redness or irritation) develop.Skin: Immediately flood affected skin with water andwash for at least 15 min. Remove and isolate all contami-nated clothing. Gently wash all affected skin areas thor-oughly with soap and water. If symptoms such as rednessor irritation develop， immediately calla physician.Transportthevictim toa hospital fortreatment.Inhalation: Remove victim to fresh air. If not breathing,give artificial respiration. If breathing is difficult, giveoxygen. Get medical attention immediately. Ingestion: Donot induce vomiting. If the victim is conscious and notconvulsing，give largeamountof water to dilute thechemical. Never give anything by mouth to an uncon-scious person. If symptoms (such as wheezing, coughing,shortness of breath, or burning in the mouth, throat, orchest) develop, call a physician. In all cases get medicalattention immediately. If the victim is convulsing orunconscious, do not give anything by mouth, ensure that .the victim's airway is open and lay the victim on his/herside with the head lower than the body.

• Lager

  Color Code- White stripe (store separately):Contact Hazard; not compatible with materials in solidwhite category. Storage precautions: you should store thischemical in a refrigerator and keep it away from ox idizingmaterials. Store away from sources of ignition. Protectiveclothing (minimum protective clothing): if Tyvek-typedisposable protective clothing is not worn during handlingof this chemical, wear disposable Tyvek-type sleeves tapedto your gloves.

• Versand/Shipping

  UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

• läuterung methode

  Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.

• Inkompatibilitäten

  HFIP is incompatible with acids, acid chlorides, and oxidizing agents.

• Waste disposal

  May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

1,1,1,3,3,3-Hexafluoro-2-propanol Upstream-Materialien And Downstream Produkte

1,1,1,3,3,3-Hexafluorpropan-2-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(692)Suppliers

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