Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Struktur

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

Bezeichnung:Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

CAS-Nr159749-28-7

Englisch Name:Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

CBNumberCB3215522

SummenformelC9H15NO4

Molgewicht201.22

MOL-Datei159749-28-7.mol

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester physikalisch-chemischer Eigenschaften

Siedepunkt	321.0±35.0 °C(Predicted)
Dichte	1.246±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.01±0.20(Predicted)
Aggregatzustand	solid
Farbe	Pale yellow

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	36/37/38-50
S-Sätze:	26-36-61-24/25
RIDADR	UN3077
WGK Germany	3
HS Code	29339900

Gefahreninformationscode (GHS)

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester (ADCBT) is a pyrrolidinyl nicotinic acetylcholine receptor agonist. ADCBT has been shown to have affinity values for neuronal nicotinic acetylcholine receptors that are significantly higher than those of nicotine. It has been shown to be regioselective in the sense that it binds preferentially to the alpha4beta2 subtype of the nicotinic acetylcholine receptor, which is present in both peripheral and central neurons. It also has a high affinity for the acetylcholine binding site at the neuromuscular junction. ADCBT has been shown to have analgesic effects in animal studies.
Chemische Eigenschaften
White powder
Verwenden
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester, is an useful intermediate in the synthesis of pharmaceutical compounds including inhibitors and receptor Antagonists. It can be used in the synthesis of polypeptides.
synthetische
Sodium hydroxide (2.08 g, 51.92 mmol) was added to a solution of azetidine-2-carboxylic acid (5.00 g, 49.50 mmol), di-tert-butyl dicarbonate (13.50 g, 61.80 mmol) in ethanol (120.0 mL) at 0 °C. After stirring the reaction mixture for 8 hours, the pH of the mixture was adjusted to 2 with 1.0 N HCl and extracted with ethyl acetate (2 × 200 mL). The combined organic layers were washed with brine, separated, and dried over anhydrous sodium sulfate. Then the compound was concentrated under reduced pressure to afford Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester.

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Upstream-Materialien And Downstream Produkte

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

159749-28-7, Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Verwandte Suche:

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