Allantoin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

Allantoin Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Beschreibung

  Allantoin is a product of purine and uric acid metabolism. It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset. Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.

• Chemische Eigenschaften

  White Solid

• Originator

  Allantoin ,Arocor Holdings Inc.

• Verwenden

  allantoin is a botanical extract said to be healing, calming, and soothing, it can also help protect the skin from harmful external factors (e.g., wind burn). It is considered an excellent temporary anti-irritant and is believed to stimulate new tissue growth, helping heal damaged skin. Allantoin is appropriate for sensitive, irritated, and acne skins. Derived from the comfrey root, it is considered non-allergenic.

• Verwenden

  diuretic

• Verwenden

  wound healing agent

• Verwenden

  Vulnerary; debriding agent. Purine metabolite via the uric acid pathway.

• Definition

  ChEBI: An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.

• Manufacturing Process

  To a mixture of 13.14 kg 40% solution of glyoxal in water and a solution of 0.5 L of concentrated HCl in 3 L of water was added 1.8 g Co(NO3)2·6H2O. The mixture was heated at 50-60°C, to the solution was added 20 g of sodium nitrite and then at 40-60°C was added dropwise the mixture of 6 L of concentrated HNO3, 4.2 L of water and 30 g of sodium nitrite. The product obtained was mixed with 2.4 kg ammonium sulfate and filtrated. The filtrate was heated with 14.5 kg urea at 70°C for 10 hours. Allantoin was filtrated and recrystallized from the water; M.P. 233-235°C.

• Therapeutic Function

  Vulnerary, Antiulcer (topical), Antipsoriatic

• Allgemeine Beschreibung

  Allantoin, the final catabolic product of purines in mammals, is a highly polar and amphoteric substance. Allantoin is mainly used for skin protection as the drug promotes cell proliferation and wound healing.
  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

• Flammability and Explosibility

  Non flammable

• Biochem/physiol Actions

  Purine metabolite via the uric acid pathway. Uric acid also reacts with free radicals to produce allantoin, thus allantoin may be a useful biomarker for oxidative stress.

• läuterung methode

  It crystallises from water or EtOH [Hartman et al. Org Synth Coll Vol II 21 1943]. [Beilstein 25 III/IV 4071.]

Allantoin Upstream-Materialien And Downstream Produkte

Allantoin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(902)Suppliers

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