BIOTIN HYDRAZIDE Struktur

BIOTIN HYDRAZIDE

Bezeichnung:BIOTIN HYDRAZIDE

CAS-Nr66640-86-6

Englisch Name:BIOTIN HYDRAZIDE

CBNumberCB3175354

SummenformelC10H18N4O2S

Molgewicht258.34

MOL-Datei66640-86-6.mol

BIOTIN HYDRAZIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	245-247 °C
Siedepunkt	633.1±40.0 °C(Predicted)
Dichte	1.243±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: ≤20 mg/mL
Aggregatzustand	powder
pka	13.25±0.35(Predicted)
Farbe	White to Almost white
BRN	28347
InChIKey	KOZWHQPRAOJMBN-ZKWXMUAHSA-N
CAS Datenbank	66640-86-6(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
F	10
HS Code	29349990

Gefahreninformationscode (GHS)

BIOTIN HYDRAZIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Biotin hydrazide is a biotinyl derivative used to label surface functional groups, antibodies, lectins, sugars, nucleic acids, or molecules with free carboxylic or keto groups. Biotin hydrazide is used as a probe for determining protein carbonylation, an irreversible posttranslational modification resulting from the actions of reactive oxygen species or lipid oxidation products. The reaction of this probe is direct and does not require catalysts or reducing agents.
Chemische Eigenschaften
3.6
Verwenden
Biotin Hydrazide is a carbohydrate reactive biotinylation reagent used predominately for labeling monoclonal antibodies, unpaired cytosine residues in nucleic acids and glycoproteins.
Verwenden
aldehyde reactive biotinylation reagent
Verwenden
(+)-Biotin hydrazide has been used:
- the modification of alginate
- for the labelling of mitochondrial proteins from non-muscle tissues
- as a component of glycoprotein staining solution
- in periodic acid-biotin-hydrazide (PABH) assay for mucins
- for labeling surface functional groups, biologically active molecules such as antibodies, lectins, sugars, nucleic acids or molecules with free carboxylic or keto groups.
- for coupling to glycoproteins through the carbohydrate by hydrazone formation
Allgemeine Beschreibung
Biotin hydrazide is a biotinylation reagent used to biotinylate glycoproteins with their sugar moieties. Biotin hydrazide can be used to prepare biotin-conjugated alginate. It can also be used for covalent attachment to PAAc via carbodi-imide cross linking.
läuterung methode
Wash the hydrazide with H2O, dry it, wash it with MeOH then Et2O, and dry. Recrystallise it from hot H2O (clusters of prisms) [Hofmann et al. J Biol Chem 144 513 1942]. [Beilstein 27 III/IV 7980.]

BIOTIN HYDRAZIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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