JC-1 Struktur

JC-1

Bezeichnung:JC-1

CAS-Nr47729-63-5

Englisch Name:JC-1

CBNumberCB3168099

SummenformelC25H27Cl4IN4

Molgewicht652.22

MOL-Datei47729-63-5.mol

JC-1 physikalisch-chemischer Eigenschaften

storage temp.	-20C
Löslichkeit	DMSO: 5mg/mL
Aggregatzustand	solid
Farbe	red-orange

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10-21
HS Code	2933998090

Gefahreninformationscode (GHS)

JC-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
JC-1 is commonly used to determine mitochondrial membrane potential. It is a cationic carbocyanine dye that is membrane permeable and is often used for flow cytometry and fluorescent microscopy. This dye changes color as the membrane potential increases. At higher potentials, JC-1 forms aggregates, which changes the fluorescence emission color from green to red. Dyes and metabolites.
Definition
ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.
Allgemeine Beschreibung
A cationic, fluorescent, carbocyanine dye that can be used as a ratiometric indicator of mitochondrial potential ΔΨ_m in cells, tissues, and isolated mitochondria. It labels mitochondria with high membrane potential orange and mitochondria with low membrane potential green. Mitochondrial depolarization is indicated by a decrease in the red/green fluorescence intensity ratio. Ideal for detection of collapse of ΔΨ_m induced by uncouplers of mitochondrial respiration. The potential-sensitive color shift is due to concentration-dependent formation of red fluorescent J-aggregates. JC-1 has also been used in a functional assay of multidrug-resistance cells and in apoptosis-related mitochondrial modifications.
Biochem/physiol Actions
Product does not compete with ATP.
Lager
-20°C

JC-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

47729-63-5, JC-1 Verwandte Suche:

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