Propionylchlorid

Bezeichnung:Propionylchlorid

CAS-Nr79-03-8

Englisch Name:Propionyl chloride

CBNumberCB3156885

SummenformelC3H5ClO

Molgewicht92.52

MOL-Datei79-03-8.mol

Synonyma

Propionylchlorid

Propionylchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	-94 °C
Siedepunkt	77-79 °C (lit.)
Dichte	1.059 g/mL at 25 °C (lit.)
Dampfdichte	3.2 (vs air)
Dampfdruck	106 hPa (20 °C)
Brechungsindex	n20/D 1.404(lit.)
Flammpunkt	53 °F
storage temp.	Store below +30°C.
Aggregatzustand	Liquid
Farbe	Clear
Säure-Base-Indikators(pH-Indikatoren)	<7.0
Explosionsgrenze	3.6-11.9%(V)
Wasserlöslichkeit	REACTS
FreezingPoint	-94℃
Sensitive	Moisture Sensitive
Merck	14,7828
BRN	385632
Expositionsgrenzwerte	ACGIH: TWA 0.1 ppm OSHA: TWA 0.1 ppm(0.4 mg/m3) NIOSH: IDLH 2 ppm; TWA 0.1 ppm(0.4 mg/m3); Ceiling 0.2 ppm(0.8 mg/m3)
InChIKey	RZWZRACFZGVKFM-UHFFFAOYSA-N
CAS Datenbank	79-03-8(CAS DataBase Reference)
NIST chemische Informationen	Propanoyl chloride(79-03-8)
EPA chemische Informationen	Propanoyl chloride (79-03-8)

Sicherheit

Kennzeichnung gefährlicher	F,C
R-Sätze:	11-14-34-20/22
S-Sätze:	9-16-26-45
RIDADR	UN 1815 3/PG 2
WGK Germany	1
RTECS-Nr.	UG6657000
Selbstentzündungstemperatur	270 °C
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29051900
HS Code	29399990
Giftige Stoffe Daten	79-03-8(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: 823 mg/kg

Gefahreninformationscode (GHS)

Propionyl chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R14:Reagiert heftig mit Wasser.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S9:Behälter an einem gut gelüfteten Ort aufbewahren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Propionyl chloride is a colorless to light yellow, volatile, and readily flammable liquid, whose vapors hydrolyze in moist air. It is corrosive, lachrymatory, and has a strongly pungent odor. With water and lower alcohols it reacts vigorously under solvolysis to give the acid or ester. It is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity.
Verwenden
Propionyl chloride is used as an intermediate in the production of agrochemicals and pharmaceuticals. It serves as an intermediate for dyes, textile auxiliaries and peroxide compounds. It acts as a crop protecting agent.
synthetische
Propionyl chloride is synthesized by reacting propionic acid with phosphorus trichloride at 40-50°C for 1h, cooling, standing, separating and distilling to obtain the product.
CH3CH2COOH+PCl3→CH3CH2COCl+HOPCl2
Propionyl chloride is produced industrially by treatment of propionic acid with phosgene or thionyl chloride. The reaction occurs at ca. 50°C in the liquid phase in the presence of dialkylformamides. The product is then separated by distillation.
CH3CH2CO2H + COCl2 → CH3CH2COCl + HCl + CO2
Propionyl chloride can also be obtained by the reaction of propionic acid with PCl5.
Application
Propionyl chloride is used for the introduction of the propionyl group and for the synthesis of propionate esters because of its high reactivity. It is an chemical intermediate in the preparation of various propionic acid derivatives, It can also be used:
To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.
For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.
Allgemeine Beschreibung
Propionyl chloride appears as a colorless liquid with a pungent odor. Corrosive and very irritating to skin and eyes. Used to make other chemicals.
Air & Water Reaktionen
Highly flammable. Propionyl chloride reacts vigorously or violently with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989].
Reaktivität anzeigen
Acid halides, such as Propionyl chloride, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Hazard
Strong irritant to skin.
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Brandgefahr
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility
Highly flammable
Sicherheitsprofil
A corrosive irritant to skin, eyes, and mucous membranes. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Reacts with water or steam to produce toxic and corrosive fumes. Exothermic reaction with diisopropyl ether produces much gas. The reaction may be dangerous if confmed. To fight fire, use CO2, dry chemical; do not use water. When heated to decomposition it emits lughly toxic fumes of Cl-. See also HYDROCHLORIC ACID.

Propionyl chloride Upstream-Materialien And Downstream Produkte

Propionylchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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