ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT

ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
  
  • as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
  • as a nonspecific agonist to assess the activity of P2×₇-R by the mobilization of Ca²⁺
  • to evaluate the physiological significance of elevated intracellular ATP levels
  • increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells
  
  

• Allgemeine Beschreibung

  A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X₇ purinergic receptors in J774 mouse macrophages. Does not affect P2_γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X₇ receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca²⁺ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.

• Biochem/physiol Actions

  Reversible: no

ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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