1,2-Dihydro-2-oxochinolin-4-carbonsure

Bezeichnung:1,2-Dihydro-2-oxochinolin-4-carbonsure

CAS-Nr15733-89-8

Englisch Name:2-Hydroxy-4-quinolincarboxylic acid

CBNumberCB3132467

SummenformelC10H7NO3

Molgewicht189.17

MOL-Datei15733-89-8.mol

Synonyma

1,2-Dihydro-2-oxochinolin-4-carbonsure

1,2-Dihydro-2-oxochinolin-4-carbonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	350°C
Siedepunkt	403.6±45.0 °C(Predicted)
Dichte	1.429±0.06 g/cm3(Predicted)
Dampfdruck	0Pa at 25℃
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Sonicated)
Aggregatzustand	Solid
pka	2.76±0.20(Predicted)
Farbe	Yellow to Dark Yellow
BRN	148331
InChI	InChI=1S/C10H7NO3/c12-9-5-7(10(13)14)6-3-1-2-4-8(6)11-9/h1-5H,(H,11,12)(H,13,14)
InChIKey	MFSHNFBQNVGXJX-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC=C2)C(C(O)=O)=CC1=O
LogP	0.3 at 25℃ and pH7
CAS Datenbank	15733-89-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36
WGK Germany	WGK 3
RTECS-Nr.	GD3869000
HazardClass	IRRITANT
HS Code	29337900
Speicherklasse	13 - Non Combustible Solids
Toxizität	mouse,LD,intraperitoneal,> 500mg/kg (500mg/kg),"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 5, Pg. 338, 1953.

Gefahreninformationscode (GHS)

2-Hydroxy-4-quinolincarboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Solid
Verwenden
1,2-Dihydro-2-oxo-4-quinolinecarboxylic Acid is a chemical constituent of vinegar Schisandra chinensis and is used as a indicator reagent in marking security documents.
Definition
ChEBI: 2-oxo-1,2-dihydroquinoline-4-carboxylic acid is a quinolinemonocarboxylic acid. It is a conjugate acid of a 2-oxo-1,2-dihydroquinoline-4-carboxylate.
Synthese

141-82-2

91-56-5

15733-89-8

1. Add 400kg of recovered glacial acetic acid to the 1000L reactor and start stirring. 2. 100kg of indigo, 160kg of malonic acid and 15kg of sodium acetate were added sequentially to the reactor to ensure adequate mixing. 3. The reaction mixture was heated to reflux and the reflux reaction was maintained for 6 hours. 4. Upon completion of the reaction, the acetic acid was removed by distillation under reduced pressure. 5. 300 kg of deionized water was added to the reaction mixture and stirred to promote crystal formation. 6. 6. The solid product was collected by filtration, washed with 30 kg of cold glacial acetic acid, and then rinsed with 30 kg of cold methanol to obtain the wet product of 2-quinolinone-4-carboxylic acid. 7. The wet product was dried at 45-70 °C for 24 h. 125 kg of 2-quinolinone-4-carboxylic acid was finally obtained with a yield of 97.3% and a liquid phase purity of 99.6%.
Einzelnachweise
[1] Patent: CN108101842, 2018, A. Location in patent: Paragraph 0021; 0023
[2] Synthetic Communications, 2005, vol. 35, # 17, p. 2243 - 2250
[3] Patent: WO2013/153357, 2013, A1. Location in patent: Page/Page column 44
[4] Patent: US2015/45354, 2015, A1. Location in patent: Paragraph 0271-0274
[5] Chemische Berichte, 1914, vol. 47, p. 358

2-Hydroxy-4-quinolincarboxylic acid Upstream-Materialien And Downstream Produkte

1,2-Dihydro-2-oxochinolin-4-carbonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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