Clortermine

Clortermine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Voranil,U.S.V.,US,1973

• Verwenden

  Anorexic.

• Definition

  ChEBI: Clortermine is a member of amphetamines.

• Manufacturing Process

  To a Grignard reagent (prepared from 50.0 g of o,α-dichloro-toluene and 7.45 g of magnesium in diethyl ether) is added 18.0 g of acetone at such rate that constant reflux is maintained. The reaction mixture is allowed to stand overnight at room temperature, and is then poured onto a mixture of 20% sulfuric acid and ice. The organic layer is separated, washed with water, an aqueous solution of sodium hydrogen carbonate and again with water, dried over magnesium sulfate and evaporated to dryness. The residue is distilled under reduced pressure to yield 42.6 g of 1-(o-chlorophenyl)-2-methyl-2- propanol, BP 120° to 122°C/12.5 mm.
  To 29.0 ml of glacial acetic acid, cooled to 15°C, is added 11.5 g of sodium cyanide (98%) while stirring, and then dropwise 32.4 ml of concentrated sulfuric acid, dissolved in 29 ml of glacial acetic acid, while maintaining a temperature of 20°C. The 1-(o-chlorophenyl)-2-methyl-2-propanol is added moderately fast, allowing the temperature to rise spontaneously. After completing the addition, the reaction mixture is heated to 70°C and stirred, and is then poured onto a mixture of water and ice. The aqueous mixture is neutralized with sodium carbonate and extracted with diethyl ether. The organic solution is washed with water, dried over magnesium sulfate and evaporated to dryness.
  The oily residue is taken up in 100 ml of 6 N aqueous hydrochloric acid and refluxed until a clear solution is obtained. The latter is made basic with aqueous ammonia and extracted with diethyl ether; the organic solution is separated, washed, dried and evaporated. The residue is distilled under reduced pressure to yield 26.3 g of 1-(o-chlorophenyl)-2-methyl-2- propylamine, BP 116° to 118°C/16 mm.
  The 1-(o-chlorophenyl)-2-methyl-2-propylamine hydrochloride is prepared by adding ethanolic hydrogen chloride to an ice-cold solution of the free base in ethanol; the desired salt precipitates and is recrystallized from ethanol, MP 245° to 246°C.
  

• Therapeutic Function

  Antiobesity

Clortermine Upstream-Materialien And Downstream Produkte

Clortermine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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