INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a K_d of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization^[1].

  CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage^[1].
  CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites^[1].
  CAM833 (0-50 μM) inhibits DNA repair by homologous recombination^[1].
  CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time^[1].
  CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation^[1].
  CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells^[1].

  Cell Cycle Analysis^[1]

• Lager

  Store at -20°C

INDEX NAME NOT YET ASSIGNED Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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