Methylthiouracil

Bezeichnung:Methylthiouracil

CAS-Nr56-04-2

Englisch Name:Methylthiouracil

CBNumberCB3108758

SummenformelC5H6N2OS

Molgewicht142.18

MOL-Datei56-04-2.mol

Synonyma

Methylthiouracil

Methylthiouracil physikalisch-chemischer Eigenschaften

Schmelzpunkt	~330 °C (dec.)(lit.)
Dichte	1.291 (estimate)
Brechungsindex	1.6430 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO (Heated), Methanol (Slightly, Heated)
Aggregatzustand	Liquid
pka	pKa 8.2 (Uncertain)
Farbe	Clear colorless to yellow
Wasserlöslichkeit	INSOLUBLE
Merck	14,6128
BRN	115648
Stabilität	Incompatible with strong oxidizing agents, iodine, metals.
InChIKey	HWGBHCRJGXAGEU-UHFFFAOYSA-N
CAS Datenbank	56-04-2(CAS DataBase Reference)
IARC	2B (Vol. Sup 7, 79) 2001
NIST chemische Informationen	6-Methyl-2-thiouracil(56-04-2)
EPA chemische Informationen	Methylthiouracil (56-04-2)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-40
S-Sätze:	36/37-45
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS-Nr.	YR0875000
Hazard Note	Irritant/Possible Carcinogen
TSCA	Yes
HS Code	29335995
Giftige Stoffe Daten	56-04-2(Hazardous Substances Data)
Toxizität	MLD in rabbits (mg/kg): 2486 orally (Simon)

Gefahreninformationscode (GHS)

Methylthiouracil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
white powder
Verwenden
antithyroid agent
Verwenden
6-?Methyl-?2-?thiouracil is a derivative of methylthiouracil (M330710), a competitive inhibitor of Nitric Oxide Synthase (NOS). Potential anti-inflammatory agent.
Definition
ChEBI: Methylthiouracil is a pyrimidone.
Allgemeine Beschreibung
White crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Methylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents .
Brandgefahr
Flash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic and reproductive effects by an unspecified route: developmental abnormalities of the endocrine system and effects on newborn including neonatal measures or effects. Experimental reproductive effects. Used to treat hyperthyroidism. When heated to decomposition it emits very toxic fumes of NOx and SOx.
läuterung methode
Crystallise the thiouracil from a large volume of H2O. Purify it further by dissolving in base, adding charcoal, filtering and acidifying with AcOH. Suspend the wet solid (ca 100g) in boiling H2O (1L), stir and add AcOH (20mL), stir and refrigerate. Collect the product, wash it with cold H2O (4 x 200mL), drain it for several hours then place it in an oven at 70o to constant weight. [IR: Short & Thompson J Chem Soc 168 1952, Foster & Snyder Org Synth Coll Vol IV 638 1063, Beilstein 24 III/IV 1289.]

Methylthiouracil Upstream-Materialien And Downstream Produkte

Methylthiouracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

56-04-2, Methylthiouracil Verwandte Suche:

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