9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol

Bezeichnung:9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol

CAS-Nr511-28-4

Englisch Name:VitaMin D4

CBNumberCB3104866

SummenformelC28H46O

Molgewicht398.66

MOL-Datei511-28-4.mol

Synonyma

9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol

9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	83-86 °C(lit.)
alpha	D18 +89.3° (c = 0.47 in acetone)
Siedepunkt	504.9±29.0 °C(Predicted)
Dichte	0.96
storage temp.	2-8°C
Löslichkeit	Soluble in Chloroform
Aggregatzustand	Powder
pka	14.74±0.20(Predicted)
Farbe	Off-white to light yellow
Stabilität	Hygroscopic, Temperature Sensitive
CAS Datenbank	511-28-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	24/25-26-48/25
S-Sätze:	28-36/37
RIDADR	UN 2811 6.1/PG 2
WGK Germany	2
RTECS-Nr.	VS2900000
F	8-10-23

Gefahreninformationscode (GHS)

VitaMin D4 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.
Chemische Eigenschaften
Pale Yellow Oil
Verwenden
Vitamin D4 is the active analogue of Vitamin D.
Definition
ChEBI: Vitamin D4 is it is present in mushrooms. It has a role as a fungal metabolite. It is a vitamin D and a seco-ergostane.
Biologische Funktion
Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.

9,10-Secoergosta-5(Z),7(E),10(19)-trien-3β-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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